TCF3

This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. RefSeq, Sep 2011
Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. TCF3 has been shown to directly enhance Hes1 (a well-known target of Notch signaling) expression.wikipedia

TCF3

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Wikipedia TCF3

Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks

myocyte - Wold - ENCSR000AIP

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Legend

Proximal:
  • H3K27ac
  • H3K27me3
  • H3K36me3
  • H3K4me1
  • H3K4me2
  • H3K4me3
  • H3K79me2
  • H3K79me3
  • H3K9ac
  • H3K9me3
  • H3ac
Distal:
  • H3K27ac
  • H3K27me3
  • H3K36me3
  • H3K4me1
  • H3K4me2
  • H3K4me3
  • H3K79me2
  • H3K79me3
  • H3K9ac
  • H3K9me3
  • H3ac

Notes

Average histone modification profiles are shown for the [-2 kb, +2 kb] window around the summits of TF ChIP-seq peaks. Profile are shown separately for peaks that are proximal ([-1 kb, +1 kb]; ending in '-p') to an annotated transcript start site (TSS) and for peaks that are distal (>1 kb; ending in '-d') to all annotated TSS. TSS-proximal profiles are arranged such that the nearest transcript proceeds towards the right.

Motifs Enriched in the Top 500 ChIP-seq Peaks

myocyte - Wold - ENCSR000AIP

1.
500 / 500
1.0e-746
GCAGGGACAGCTGCA
small heat map img p-value: 0.00
pct_center: 0.81
pct_ratio: 1.99
2.
423 / 500
2.9e-265
AGCAGCTG
small heat map img p-value: 0.00
pct_center: 0.75
pct_ratio: 2.18
3.
26 / 500
8.6e-9
GTGTGTGTGTGTGTG
small heat map img p-value: 0.01
pct_center: 0.27
pct_ratio: 0.53
4.
110 / 500
0.00015
TGGCAGGG
small heat map img p-value: 0.00
pct_center: 0.40
pct_ratio: 0.66
5.
117 / 500
0.0017
CAGCTGTG
small heat map img p-value: 0.00
pct_center: 0.52
pct_ratio: 1.63
MEME output

Notes

The top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Up to five motifs are reported (1 to 5) if they meet the criteria defined by our pipeline.

Binding of other histone marks at TCF3 peaks

myocyte - Wold - ENCSR000AIP

myocyte
Wold
TCF3
ENCSR000AIP
r=1.00

small heat map img

myocyte
Wold
H3K4me2
ENCSR000AHS
r=0.22

small heat map img

myocyte
Wold
H3ac
ENCSR000AHU
r=0.16

small heat map img

myocyte
Wold
H3K4me3
ENCSR000AHT
r=0.11

small heat map img

myocyte
Wold
H3K27me3
ENCSR000AHM
r=0.01

small heat map img

myocyte
Wold
H3K79me2
ENCSR000AHN
r=-0.02

small heat map img

myocyte
Wold
H3K36me3
ENCSR000AHV
r=-0.05

small heat map img
10,000 randomly-selected peaks from a total of 10,172 (download )

Notes

ChIP-seq peaks (left to right in the heatmap) for the current TF are sorted by descending TF ChIP-seq signal. The ChIP-seq signals of histone modifications are plotted for the genomic regions that correspond to the peaks of the current TF in the same order. The Pearson correlation coefficient (r) of the histone modification ChIP-seq signal with the TF ChIP-seq signal is shown.

legend
Binding of other TFs at TCF3 peaks

myocyte - Wold - ENCSR000AIP

myocyte
Wold
TCF3
ENCSR000AIP
r=1.00

small heat map img

myocyte
Wold
MYOD1
ENCSR000AIH
r=0.86

small heat map img

myocyte
Wold
MYOD1
ENCSR000AIR
r=0.82

small heat map img

myocyte
Wold
MYOG
ENCSR000AIC
r=0.82

small heat map img

myocyte
Wold
MYOG
ENCSR000AID
r=0.77

small heat map img

myocyte
Wold
TCF12
ENCSR000AIN
r=0.73

small heat map img

myocyte
Wold
MYOG
ENCSR000AIW
r=0.66

small heat map img

myocyte
Wold
MYOD1
ENCSR000AIT
r=0.57

small heat map img

myocyte
Wold
SRF
ENCSR000AIM
r=0.38

small heat map img

myocyte
Wold
MAX
ENCSR000AIL
r=0.28

small heat map img

myocyte
Wold
POLR2A
ENCSR000AIX
r=0.27

small heat map img

myocyte
Wold
REST
ENCSR000AIS
r=0.26

small heat map img

myocyte
Wold
E2F4
ENCSR000AII
r=0.24

small heat map img

myocyte
Wold
USF1
ENCSR000AIE
r=0.22

small heat map img

myocyte
Wold
CEBPB
ENCSR000AIB
r=0.20

small heat map img
10,000 randomly-selected peaks from a total of 10,172 (download )

Notes

Peaks (left to right in the heatmap) are sorted by the descending order of [-log10(q-value), -log10(p-value), TF ChIP-seq signal].

legend
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