MYOD1

This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. RefSeq, Jul 2008
MyoD is a protein that plays a major role in regulating muscle differentiation. MyoD, which was discovered in the laboratory of Harold M. Weintraub, belongs to a family of proteins known as myogenic regulatory factors (MRFs).wikipedia

MYOD1


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Wikipedia MYOD1

Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks

C2C12 - Wold - ENCSR000AIG

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myocyte - Wold - ENCSR000AIH

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myocyte - Wold - ENCSR000AIR

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myocyte - Wold - ENCSR000AIT

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Legend

Proximal:
  • H3K27ac
  • H3K27me3
  • H3K36me3
  • H3K4me1
  • H3K4me2
  • H3K4me3
  • H3K79me2
  • H3K79me3
  • H3K9ac
  • H3K9me3
  • H3ac
Distal:
  • H3K27ac
  • H3K27me3
  • H3K36me3
  • H3K4me1
  • H3K4me2
  • H3K4me3
  • H3K79me2
  • H3K79me3
  • H3K9ac
  • H3K9me3
  • H3ac

Notes

Average histone modification profiles are shown for the [-2 kb, +2 kb] window around the summits of TF ChIP-seq peaks. Profile are shown separately for peaks that are proximal ([-1 kb, +1 kb]; ending in '-p') to an annotated transcript start site (TSS) and for peaks that are distal (>1 kb; ending in '-d') to all annotated TSS. TSS-proximal profiles are arranged such that the nearest transcript proceeds towards the right.

Motifs Enriched in the Top 500 ChIP-seq Peaks

C2C12 - Wold - ENCSR000AIG

1.
495 / 500
4.7e-742
AGACAGGAACAGCTG
small heat map img p-value: 0.00
pct_center: 0.72
pct_ratio: 2.31
2.
195 / 500
5.5e-63
AACAGCTG
small heat map img p-value: 0.00
pct_center: 0.71
pct_ratio: 2.52
3.
109 / 500
1.6e-55
GTGACTCA
small heat map img p-value: 0.00
pct_center: 0.38
pct_ratio: 2.00
4.
29 / 500
0.00073
TGTGGCTGTCAGTCA
small heat map img p-value: 0.00
pct_center: 0.24
pct_ratio: 0.61
5.
17 / 500
12
AGGTCTGTGGCTGG
small heat map img p-value: 0.02
pct_center: 0.28
pct_ratio: 0.59
MEME output

Notes

The top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Up to five motifs are reported (1 to 5) if they meet the criteria defined by our pipeline.

myocyte - Wold - ENCSR000AIT

1.
490 / 500
2.0e-717
TGGCAGGAACAGCTGC
small heat map img p-value: 0.00
pct_center: 0.93
pct_ratio: 2.32
2.
213 / 500
2.1e-127
AACAGCTG
small heat map img p-value: 0.00
pct_center: 0.91
pct_ratio: 2.39
3.
8 / 500
0.00045
TGTGTGTGTGTGTGTGTGTGT
small heat map img p-value: 0.90
pct_center: 0.15
pct_ratio: 0.37
4.
79 / 500
0.14
AGGGACAGTGA
small heat map img p-value: 0.09
pct_center: 0.33
pct_ratio: 0.63
5.
12 / 500
1.8
GCATTTAAAAAAAGA
small heat map img p-value: 0.11
pct_center: 0.08
pct_ratio: 0.33
MEME output

myocyte - Wold - ENCSR000AIR

1.
492 / 500
1.0e-783
GCAGGAACAGCTGCA
small heat map img p-value: 0.00
pct_center: 0.89
pct_ratio: 2.50
2.
362 / 500
2.2e-185
AGCAGCTG
small heat map img p-value: 0.00
pct_center: 0.81
pct_ratio: 2.56
3.
175 / 500
5.5e-21
GGTGACAG
small heat map img p-value: 0.00
pct_center: 0.36
pct_ratio: 0.80
4.
5 / 500
1.6e+2
TGTGTGTGTGTGTGTGTGTG
small heat map img p-value: 0.95
pct_center: 0.16
pct_ratio: 0.41
5.
36 / 500
6.8
GGGGGGGGCTGGGCA
small heat map img p-value: 0.19
pct_center: 0.38
pct_ratio: 0.64
MEME output

myocyte - Wold - ENCSR000AIH

1.
496 / 500
7.6e-728
GACAGCTGCAG
small heat map img p-value: 0.00
pct_center: 0.78
pct_ratio: 2.36
2.
319 / 500
3.1e-172
AGCAGCTG
small heat map img p-value: 0.00
pct_center: 0.74
pct_ratio: 2.44
3.
199 / 500
3.5e-43
GCTGACAG
small heat map img p-value: 0.00
pct_center: 0.28
pct_ratio: 0.94
4.
60 / 500
1.8e-15
TGGGGGAGGGG
small heat map img p-value: 0.83
pct_center: 0.45
pct_ratio: 0.56
5.
156 / 500
2.3e-10
CTGGGCAG
small heat map img p-value: 0.00
pct_center: 0.36
pct_ratio: 0.75
MEME output

Notes

The top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Up to five motifs are reported (1 to 5) if they meet the criteria defined by our pipeline.

Binding of other histone marks at MYOD1 peaks

C2C12 - Wold - ENCSR000AIG

C2C12
Wold
MYOD1
ENCSR000AIG
r=1.00

small heat map img

C2C12
Wold
H3ac
ENCSR000AHP
r=0.18

small heat map img

C2C12
Wold
H3K4me3
ENCSR000AHO
r=0.06

small heat map img

C2C12
Wold
H3K79me2
ENCSR000AHQ
r=0.00

small heat map img

C2C12
Wold
H3K79me3
ENCSR000AHW
r=-0.01

small heat map img

C2C12
Wold
H3K36me3
ENCSR000AHL
r=-0.02

small heat map img

C2C12
Wold
H3K27me3
ENCSR000AHR
r=-0.03

small heat map img
10,000 randomly-selected peaks from a total of 13,040 (download )

myocyte - Wold - ENCSR000AIH

myocyte
Wold
MYOD1
ENCSR000AIH
r=1.00

small heat map img

myocyte
Wold
MYOD1
ENCSR000AIR
r=0.89

small heat map img

myocyte
Wold
MYOD1
ENCSR000AIT
r=0.54

small heat map img

myocyte
Wold
H3K4me2
ENCSR000AHS
r=0.24

small heat map img

myocyte
Wold
H3ac
ENCSR000AHU
r=0.15

small heat map img

myocyte
Wold
H3K4me3
ENCSR000AHT
r=0.12

small heat map img

myocyte
Wold
H3K27me3
ENCSR000AHM
r=0.01

small heat map img

myocyte
Wold
H3K79me2
ENCSR000AHN
r=-0.00

small heat map img

myocyte
Wold
H3K36me3
ENCSR000AHV
r=-0.03

small heat map img
10,000 randomly-selected peaks from a total of 29,226 (download )

myocyte - Wold - ENCSR000AIR

myocyte
Wold
MYOD1
ENCSR000AIR
r=1.00

small heat map img

myocyte
Wold
MYOD1
ENCSR000AIH
r=0.90

small heat map img

myocyte
Wold
MYOD1
ENCSR000AIT
r=0.62

small heat map img

myocyte
Wold
H3K4me2
ENCSR000AHS
r=0.25

small heat map img

myocyte
Wold
H3ac
ENCSR000AHU
r=0.14

small heat map img

myocyte
Wold
H3K4me3
ENCSR000AHT
r=0.11

small heat map img

myocyte
Wold
H3K27me3
ENCSR000AHM
r=0.01

small heat map img

myocyte
Wold
H3K79me2
ENCSR000AHN
r=-0.01

small heat map img

myocyte
Wold
H3K36me3
ENCSR000AHV
r=-0.04

small heat map img
10,000 randomly-selected peaks from a total of 20,160 (download )

myocyte - Wold - ENCSR000AIT

myocyte
Wold
MYOD1
ENCSR000AIT
r=1.00

small heat map img

myocyte
Wold
MYOD1
ENCSR000AIR
r=0.81

small heat map img

myocyte
Wold
MYOD1
ENCSR000AIH
r=0.79

small heat map img

myocyte
Wold
H3K4me2
ENCSR000AHS
r=0.31

small heat map img

myocyte
Wold
H3ac
ENCSR000AHU
r=0.10

small heat map img

myocyte
Wold
H3K4me3
ENCSR000AHT
r=0.09

small heat map img

myocyte
Wold
H3K27me3
ENCSR000AHM
r=-0.02

small heat map img

myocyte
Wold
H3K79me2
ENCSR000AHN
r=-0.03

small heat map img

myocyte
Wold
H3K36me3
ENCSR000AHV
r=-0.06

small heat map img
3,239 peaks (download )

Notes

ChIP-seq peaks (left to right in the heatmap) for the current TF are sorted by descending TF ChIP-seq signal. The ChIP-seq signals of histone modifications are plotted for the genomic regions that correspond to the peaks of the current TF in the same order. The Pearson correlation coefficient (r) of the histone modification ChIP-seq signal with the TF ChIP-seq signal is shown.

legend
Binding of other TFs at MYOD1 peaks

C2C12 - Wold - ENCSR000AIG

C2C12
Wold
MYOD1
ENCSR000AIG
r=1.00

small heat map img

C2C12
Wold
MAX
ENCSR000AIO
r=0.45

small heat map img

C2C12
Wold
FOSL1
ENCSR000AIK
r=0.37

small heat map img

C2C12
Wold
CEBPB
ENCSR000AIV
r=0.30

small heat map img

C2C12
Wold
USF1
ENCSR000AIQ
r=0.28

small heat map img

C2C12
Wold
MYOG
ENCSR000AIF
r=0.23

small heat map img

C2C12
Wold
CTCF
ENCSR000AIJ
r=0.14

small heat map img
10,000 randomly-selected peaks from a total of 13,040 (download )

myocyte - Wold - ENCSR000AIH

myocyte
Wold
MYOD1
ENCSR000AIH
r=1.00

small heat map img

myocyte
Wold
MYOD1
ENCSR000AIR
r=0.89

small heat map img

myocyte
Wold
MYOG
ENCSR000AIC
r=0.85

small heat map img

myocyte
Wold
TCF3
ENCSR000AIP
r=0.77

small heat map img

myocyte
Wold
MYOG
ENCSR000AID
r=0.73

small heat map img

myocyte
Wold
TCF12
ENCSR000AIN
r=0.70

small heat map img

myocyte
Wold
MYOG
ENCSR000AIW
r=0.63

small heat map img

myocyte
Wold
MYOD1
ENCSR000AIT
r=0.54

small heat map img

myocyte
Wold
SRF
ENCSR000AIM
r=0.35

small heat map img

myocyte
Wold
REST
ENCSR000AIS
r=0.30

small heat map img

myocyte
Wold
POLR2A
ENCSR000AIX
r=0.28

small heat map img

myocyte
Wold
MAX
ENCSR000AIL
r=0.25

small heat map img

myocyte
Wold
E2F4
ENCSR000AII
r=0.21

small heat map img

myocyte
Wold
USF1
ENCSR000AIE
r=0.21

small heat map img

myocyte
Wold
CEBPB
ENCSR000AIB
r=0.17

small heat map img
10,000 randomly-selected peaks from a total of 29,226 (download )

myocyte - Wold - ENCSR000AIR

myocyte
Wold
MYOD1
ENCSR000AIR
r=1.00

small heat map img

myocyte
Wold
MYOD1
ENCSR000AIH
r=0.90

small heat map img

myocyte
Wold
MYOG
ENCSR000AIC
r=0.80

small heat map img

myocyte
Wold
TCF3
ENCSR000AIP
r=0.77

small heat map img

myocyte
Wold
TCF12
ENCSR000AIN
r=0.74

small heat map img

myocyte
Wold
MYOG
ENCSR000AID
r=0.72

small heat map img

myocyte
Wold
MYOG
ENCSR000AIW
r=0.67

small heat map img

myocyte
Wold
MYOD1
ENCSR000AIT
r=0.62

small heat map img

myocyte
Wold
SRF
ENCSR000AIM
r=0.35

small heat map img

myocyte
Wold
MAX
ENCSR000AIL
r=0.26

small heat map img

myocyte
Wold
REST
ENCSR000AIS
r=0.25

small heat map img

myocyte
Wold
POLR2A
ENCSR000AIX
r=0.24

small heat map img

myocyte
Wold
USF1
ENCSR000AIE
r=0.22

small heat map img

myocyte
Wold
E2F4
ENCSR000AII
r=0.21

small heat map img

myocyte
Wold
CEBPB
ENCSR000AIB
r=0.19

small heat map img
10,000 randomly-selected peaks from a total of 20,160 (download )

myocyte - Wold - ENCSR000AIT

myocyte
Wold
MYOD1
ENCSR000AIT
r=1.00

small heat map img

myocyte
Wold
MYOD1
ENCSR000AIR
r=0.81

small heat map img

myocyte
Wold
TCF12
ENCSR000AIN
r=0.80

small heat map img

myocyte
Wold
MYOD1
ENCSR000AIH
r=0.79

small heat map img

myocyte
Wold
MYOG
ENCSR000AIW
r=0.78

small heat map img

myocyte
Wold
TCF3
ENCSR000AIP
r=0.71

small heat map img

myocyte
Wold
MYOG
ENCSR000AIC
r=0.67

small heat map img

myocyte
Wold
MYOG
ENCSR000AID
r=0.58

small heat map img

myocyte
Wold
SRF
ENCSR000AIM
r=0.35

small heat map img

myocyte
Wold
MAX
ENCSR000AIL
r=0.33

small heat map img

myocyte
Wold
USF1
ENCSR000AIE
r=0.27

small heat map img

myocyte
Wold
CEBPB
ENCSR000AIB
r=0.27

small heat map img

myocyte
Wold
POLR2A
ENCSR000AIX
r=0.23

small heat map img

myocyte
Wold
E2F4
ENCSR000AII
r=0.23

small heat map img

myocyte
Wold
REST
ENCSR000AIS
r=0.22

small heat map img
3,239 peaks (download )

Notes

Peaks (left to right in the heatmap) are sorted by the descending order of [-log10(q-value), -log10(p-value), TF ChIP-seq signal].

legend
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