MYB

This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. RefSeq, Jun 2009
Myb proto-oncogene protein also known as transcriptional activator Myb is a protein that in humans is encoded by the MYB gene.wikipedia

MYB


ENCODE experiments
Ensemble search
Entrez 4602
GO search
Gene Card search
HGNC search
RefSeq search
UCSC browse
UniProt search
Wikipedia MYB_(gene)

Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks

MEL cell line - Snyder - ENCSR000ETR

loading

Legend

Proximal:
  • H3K27ac
  • H3K27me3
  • H3K36me3
  • H3K4me1
  • H3K4me2
  • H3K4me3
  • H3K79me2
  • H3K79me3
  • H3K9ac
  • H3K9me3
  • H3ac
Distal:
  • H3K27ac
  • H3K27me3
  • H3K36me3
  • H3K4me1
  • H3K4me2
  • H3K4me3
  • H3K79me2
  • H3K79me3
  • H3K9ac
  • H3K9me3
  • H3ac

Notes

Average histone modification profiles are shown for the [-2 kb, +2 kb] window around the summits of TF ChIP-seq peaks. Profile are shown separately for peaks that are proximal ([-1 kb, +1 kb]; ending in '-p') to an annotated transcript start site (TSS) and for peaks that are distal (>1 kb; ending in '-d') to all annotated TSS. TSS-proximal profiles are arranged such that the nearest transcript proceeds towards the right.

Motifs Enriched in the Top 500 ChIP-seq Peaks

MEL cell line - Snyder - ENCSR000ETR

1.
452 / 500
1.4e-264
TGGCAGTTGGT
small heat map img p-value: 0.00
pct_center: 0.26
pct_ratio: 2.51
2.
261 / 500
2.0e-99
CAGATAAG
small heat map img p-value: 0.00
pct_center: 0.28
pct_ratio: 2.47
3.
37 / 500
2.0e-12
GGGGTGGGGC
small heat map img p-value: 0.18
pct_center: 0.27
pct_ratio: 0.54
4.
21 / 500
7.8e-9
GTTTTTTTTTTTTTTTTTTA
small heat map img p-value: 0.25
pct_center: 0.24
pct_ratio: 0.41
5.
45 / 500
4.4e-7
CTGTGGTT
small heat map img p-value: 0.00
pct_center: 0.17
pct_ratio: 0.92
MEME output

Notes

The top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Up to five motifs are reported (1 to 5) if they meet the criteria defined by our pipeline.

Binding of other histone marks at MYB peaks

MEL cell line - Snyder - ENCSR000ETR

MEL cell line
Snyder
MYB
ENCSR000ETR
r=1.00

small heat map img

MEL cell line
Snyder
H3K27ac
ENCSR000CEV
r=0.57

small heat map img

MEL cell line
Snyder
H3K4me1
ENCSR000ADQ
r=0.44

small heat map img

MEL cell line
Snyder
H3K9ac
ENCSR000CEU
r=0.41

small heat map img

MEL cell line
Snyder
H3K4me3
ENCSR000ADR
r=0.41

small heat map img

MEL cell line
Snyder
H3K36me3
ENCSR000CES
r=0.40

small heat map img

MEL cell line
Snyder
H3K4me1
ENCSR000ADY
r=0.40

small heat map img

MEL cell line
Snyder
H3K4me3
ENCSR000AEA
r=0.40

small heat map img

MEL cell line
Snyder
H3K4me1
ENCSR000CEW
r=0.36

small heat map img

MEL cell line
Snyder
H3K4me3
ENCSR000CEX
r=0.31

small heat map img

MEL cell line
Snyder
H3K79me2
ENCSR000CET
r=0.18

small heat map img

MEL cell line
Snyder
H3K9me3
ENCSR000ADT
r=0.16

small heat map img

MEL cell line
Snyder
H3K9me3
ENCSR000AEB
r=0.16

small heat map img

MEL cell line
Snyder
H3K27me3
ENCSR000ADW
r=0.15

small heat map img

MEL cell line
Snyder
H3K27me3
ENCSR000ADP
r=0.11

small heat map img

MEL cell line
Snyder
H3K36me3
ENCSR000ADX
r=0.08

small heat map img

MEL cell line
Snyder
H3K27me3
ENCSR000CER
r=0.03

small heat map img
3,998 peaks (download )

Notes

ChIP-seq peaks (left to right in the heatmap) for the current TF are sorted by descending TF ChIP-seq signal. The ChIP-seq signals of histone modifications are plotted for the genomic regions that correspond to the peaks of the current TF in the same order. The Pearson correlation coefficient (r) of the histone modification ChIP-seq signal with the TF ChIP-seq signal is shown.

legend
Binding of other TFs at MYB peaks

MEL cell line - Snyder - ENCSR000ETR

MEL cell line
Snyder
MYB
ENCSR000ETR
r=1.00

small heat map img

MEL cell line
Snyder
EP300
ENCSR000ETP
r=0.88

small heat map img

MEL cell line
Snyder
EP300
ENCSR000ETV
r=0.83

small heat map img

MEL cell line
Snyder
ETS1
ENCSR000ETB
r=0.79

small heat map img

MEL cell line
Snyder
SIN3A
ENCSR000ETC
r=0.79

small heat map img

MEL cell line
Snyder
RCOR1
ENCSR000ESI
r=0.78

small heat map img

MEL cell line
Snyder
CHD2
ENCSR000ETO
r=0.78

small heat map img

MEL cell line
Snyder
MAFK
ENCSR000ETK
r=0.78

small heat map img

MEL cell line
Snyder
KAT2A
ENCSR000ESM
r=0.78

small heat map img

MEL cell line
Snyder
GATA1
ENCSR000EUG
r=0.78

small heat map img

MEL cell line
Snyder
JUND
ENCSR000ETZ
r=0.74

small heat map img

MEL cell line
Snyder
BHLHE40
ENCSR000ESH
r=0.74

small heat map img

MEL cell line
Snyder
MYC
ENCSR000EUA
r=0.74

small heat map img

MEL cell line
Snyder
MAZ
ENCSR000ESL
r=0.72

small heat map img

MEL cell line
Snyder
MAX
ENCSR000ETX
r=0.71

small heat map img

MEL cell line
Snyder
E2F4
ENCSR000ETY
r=0.70

small heat map img

MEL cell line
Snyder
GATA1
ENCSR000ETA
r=0.70

small heat map img

MEL cell line
Snyder
ZMIZ1
ENCSR000ESE
r=0.68

small heat map img

MEL cell line
Snyder
TBP
ENCSR000EUB
r=0.68

small heat map img

MEL cell line
Snyder
GABPA
ENCSR000ESK
r=0.67

small heat map img

MEL cell line
Snyder
MXI1
ENCSR000ETN
r=0.67

small heat map img

MEL cell line
Snyder
ZC3H11A
ENCSR000ESF
r=0.66

small heat map img

MEL cell line
Snyder
NELFE
ENCSR000ETU
r=0.66

small heat map img

MEL cell line
Snyder
SMC3
ENCSR000ETL
r=0.65

small heat map img

MEL cell line
Snyder
ZKSCAN1
ENCSR000ESX
r=0.64

small heat map img

MEL cell line
Snyder
TAL1
ENCSR000DIA
r=0.61

small heat map img

MEL cell line
Snyder
HCFC1
ENCSR000ESG
r=0.53

small heat map img

MEL cell line
Snyder
CHD1
ENCSR000ESN
r=0.52

small heat map img

MEL cell line
Snyder
RAD21
ENCSR000ETS
r=0.51

small heat map img

MEL cell line
Snyder
ZNF384
ENCSR000ESD
r=0.49

small heat map img

MEL cell line
Snyder
MAFK
ENCSR000ESY
r=0.49

small heat map img

MEL cell line
Snyder
USF2
ENCSR000ETF
r=0.49

small heat map img

MEL cell line
Snyder
POLR2A
ENCSR000EUC
r=0.47

small heat map img

MEL cell line
Snyder
UBTF
ENCSR000ESJ
r=0.47

small heat map img

MEL cell line
Snyder
RAD21
ENCSR000ETT
r=0.45

small heat map img

MEL cell line
Snyder
POLR2A
ENCSR000ETG
r=0.44

small heat map img

MEL cell line
Snyder
POLR2A
ENCSR000CFI
r=0.32

small heat map img

MEL cell line
Snyder
CTCF
ENCSR000ETQ
r=0.29

small heat map img

MEL cell line
Snyder
CTCF
ENCSR000ETE
r=0.26

small heat map img

MEL cell line
Snyder
CTCF
ENCSR000CFH
r=0.21

small heat map img

MEL cell line
Snyder
USF2
ENCSR000ETW
r=0.20

small heat map img

MEL cell line
Snyder
CTCF
ENCSR000DIP
r=0.03

small heat map img
3,998 peaks (download )

Notes

Peaks (left to right in the heatmap) are sorted by the descending order of [-log10(q-value), -log10(p-value), TF ChIP-seq signal].

legend
Help