MEF2A

The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.RefSeq, Jan 2010
Myocyte-specific enhancer factor 2A is a protein that in humans is encoded by the MEF2A gene. MEF2A is a transcription factor in the Mef2 family.wikipedia

MEF2A

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PDB 1C7U

PDB 1C7U 1EGW 1LEW 3KOV 3MU6 3P57
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Wikipedia MEF2A

Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks

CH12.LX - Snyder - ENCSR806JZK

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MEL cell line - Snyder - ENCSR867SDZ

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Legend

Proximal:
  • H3K27ac
  • H3K27me3
  • H3K36me3
  • H3K4me1
  • H3K4me2
  • H3K4me3
  • H3K79me2
  • H3K79me3
  • H3K9ac
  • H3K9me3
  • H3ac
Distal:
  • H3K27ac
  • H3K27me3
  • H3K36me3
  • H3K4me1
  • H3K4me2
  • H3K4me3
  • H3K79me2
  • H3K79me3
  • H3K9ac
  • H3K9me3
  • H3ac

Notes

Average histone modification profiles are shown for the [-2 kb, +2 kb] window around the summits of TF ChIP-seq peaks. Profile are shown separately for peaks that are proximal ([-1 kb, +1 kb]; ending in '-p') to an annotated transcript start site (TSS) and for peaks that are distal (>1 kb; ending in '-d') to all annotated TSS. TSS-proximal profiles are arranged such that the nearest transcript proceeds towards the right.

Motifs Enriched in the Top 500 ChIP-seq Peaks

CH12.LX - Snyder - ENCSR806JZK

1.
488 / 500
2.4e-439
GTTCTAAAAATAGCA
small heat map img p-value: 0.00
pct_center: 0.23
pct_ratio: 1.64
2.
130 / 500
3.9e-52
TGAGTCAT
small heat map img p-value: 0.00
pct_center: 0.17
pct_ratio: 1.48
3.
113 / 500
3.5e-42
AAAGAGGAAGTGAAA
small heat map img p-value: 0.00
pct_center: 0.38
pct_ratio: 0.65
4.
37 / 500
1.5e-18
GGGGGTGGGGG
small heat map img p-value: 0.02
pct_center: 0.29
pct_ratio: 0.59
5.
85 / 500
1.4e-15
TGAGGTCA
small heat map img p-value: 0.00
pct_center: 0.15
pct_ratio: 0.77
MEME output

Notes

The top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Up to five motifs are reported (1 to 5) if they meet the criteria defined by our pipeline.

MEL cell line - Snyder - ENCSR867SDZ

1.
417 / 500
4.1e-453
TGCTAAAAATAGCAA
small heat map img p-value: 0.00
pct_center: 0.58
pct_ratio: 3.03
2.
247 / 500
4.3e-99
CAGATAAG
small heat map img p-value: 0.00
pct_center: 0.34
pct_ratio: 3.65
3.
69 / 500
3.1e-25
GCGAGGGGCAGGGGGCAGGGGGGGGGGGGG
small heat map img p-value: 0.00
pct_center: 0.38
pct_ratio: 0.57
4.
18 / 500
8.0e-13
GGGTGTGTGTGTGTG
small heat map img p-value: 0.47
pct_center: 0.18
pct_ratio: 0.41
5.
69 / 500
6.2e-11
AAAGAGGAAGT
small heat map img p-value: 0.00
pct_center: 0.33
pct_ratio: 0.82
MEME output

Notes

The top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Up to five motifs are reported (1 to 5) if they meet the criteria defined by our pipeline.

Binding of other histone marks at MEF2A peaks

No histone modification ChIP-seq data are available in the corresponding cell type


Notes

ChIP-seq peaks (left to right in the heatmap) for the current TF are sorted by descending TF ChIP-seq signal. The ChIP-seq signals of histone modifications are plotted for the genomic regions that correspond to the peaks of the current TF in the same order. The Pearson correlation coefficient (r) of the histone modification ChIP-seq signal with the TF ChIP-seq signal is shown.

legend
Binding of other TFs at MEF2A peaks

Notes

Peaks (left to right in the heatmap) are sorted by the descending order of [-log10(q-value), -log10(p-value), TF ChIP-seq signal].

legend
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