JUN

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. RefSeq, Jul 2008
c-Jun is a protein that in humans is encoded by the JUN gene. c-Jun in combination with c-Fos, forms the AP-1 early response transcription factor.wikipedia

JUN

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Wikipedia C-jun

Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks

CH12.LX - Snyder - ENCSR000ERO

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Legend

Proximal:
  • H3K27ac
  • H3K27me3
  • H3K36me3
  • H3K4me1
  • H3K4me2
  • H3K4me3
  • H3K79me2
  • H3K79me3
  • H3K9ac
  • H3K9me3
  • H3ac
Distal:
  • H3K27ac
  • H3K27me3
  • H3K36me3
  • H3K4me1
  • H3K4me2
  • H3K4me3
  • H3K79me2
  • H3K79me3
  • H3K9ac
  • H3K9me3
  • H3ac

Notes

Average histone modification profiles are shown for the [-2 kb, +2 kb] window around the summits of TF ChIP-seq peaks. Profile are shown separately for peaks that are proximal ([-1 kb, +1 kb]; ending in '-p') to an annotated transcript start site (TSS) and for peaks that are distal (>1 kb; ending in '-d') to all annotated TSS. TSS-proximal profiles are arranged such that the nearest transcript proceeds towards the right.

Motifs Enriched in the Top 500 ChIP-seq Peaks

CH12.LX - Snyder - ENCSR000ERO

1.
500 / 500
1.7e-332
GGAAAAAATGACTCA
small heat map img p-value: 0.00
pct_center: 0.32
pct_ratio: 1.48
2.
94 / 500
1.3e-52
GATGAGGTCAT
small heat map img p-value: 0.00
pct_center: 0.24
pct_ratio: 1.77
3.
23 / 500
8.3e-34
AAAAAAAAAAAAAAAAAAGCA
small heat map img p-value: 0.39
pct_center: 0.27
pct_ratio: 0.44
4.
69 / 500
1.3e-15
TGAAATGACTCAGCA
small heat map img p-value: 0.00
pct_center: 0.31
pct_ratio: 2.12
5.
43 / 500
2.5e-7
GGAACTGAAAC
small heat map img p-value: 0.00
pct_center: 0.38
pct_ratio: 0.75
MEME output

Notes

The top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Up to five motifs are reported (1 to 5) if they meet the criteria defined by our pipeline.

Binding of other histone marks at JUN peaks

CH12.LX - Snyder - ENCSR000ERO

CH12.LX
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JUN
ENCSR000ERO
r=1.00

small heat map img

CH12.LX
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H3K4me2
ENCSR000CGI
r=0.39

small heat map img

CH12.LX
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H3K27ac
ENCSR000CGJ
r=0.33

small heat map img

CH12.LX
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H3K4me1
ENCSR000DHQ
r=0.32

small heat map img

CH12.LX
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H3K9ac
ENCSR000CGL
r=0.32

small heat map img

CH12.LX
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H3K4me1
ENCSR000CGH
r=0.29

small heat map img

CH12.LX
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H3K4me3
ENCSR000CGK
r=0.22

small heat map img

CH12.LX
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H3K4me3
ENCSR000ADI
r=0.20

small heat map img

CH12.LX
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H3K4me3
ENCSR000DHU
r=0.12

small heat map img

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H3K79me2
ENCSR000CGM
r=0.11

small heat map img

CH12.LX
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H3K27me3
ENCSR000DHY
r=0.02

small heat map img

CH12.LX
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H3K36me3
ENCSR000CFL
r=0.00

small heat map img

CH12.LX
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H3K9me3
ENCSR000DHO
r=-0.04

small heat map img

CH12.LX
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H3K36me3
ENCSR000DHW
r=-0.04

small heat map img
10,000 randomly-selected peaks from a total of 16,619 (download )

Notes

ChIP-seq peaks (left to right in the heatmap) for the current TF are sorted by descending TF ChIP-seq signal. The ChIP-seq signals of histone modifications are plotted for the genomic regions that correspond to the peaks of the current TF in the same order. The Pearson correlation coefficient (r) of the histone modification ChIP-seq signal with the TF ChIP-seq signal is shown.

legend
Binding of other TFs at JUN peaks

CH12.LX - Snyder - ENCSR000ERO

CH12.LX
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JUN
ENCSR000ERO
r=1.00

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JUND
ENCSR000ERR
r=0.93

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EP300
ENCSR000ERI
r=0.85

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ETS1
ENCSR000ERA
r=0.79

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RCOR1
ENCSR000EQZ
r=0.78

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MAFK
ENCSR000ERB
r=0.76

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MYC
ENCSR000ERN
r=0.72

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CHD2
ENCSR000ERF
r=0.72

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MAZ
ENCSR000EQT
r=0.69

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E2F4
ENCSR000ERU
r=0.68

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BHLHE40
ENCSR000ERC
r=0.68

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SIN3A
ENCSR000EQY
r=0.67

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KAT2A
ENCSR000EQU
r=0.67

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MAX
ENCSR000ERL
r=0.66

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GABPA
ENCSR000EQS
r=0.61

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SMC3
ENCSR000ERG
r=0.60

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MXI1
ENCSR000ERE
r=0.60

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ZC3H11A
ENCSR000EQQ
r=0.60

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ZKSCAN1
ENCSR000EQW
r=0.59

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NELFE
ENCSR000ERD
r=0.58

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TBP
ENCSR000ERP
r=0.58

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RAD21
ENCSR000ERK
r=0.57

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ZMIZ1
ENCSR000EQP
r=0.55

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USF2
ENCSR000ERJ
r=0.54

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CHD1
ENCSR000EQV
r=0.52

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HCFC1
ENCSR000EQR
r=0.52

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ZNF384
ENCSR000EQO
r=0.50

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UBTF
ENCSR000EQX
r=0.50

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POLR2A
ENCSR000ERQ
r=0.40

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CTCF
ENCSR000ERM
r=0.26

small heat map img

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CTCF
ENCSR000DIU
r=0.07

small heat map img

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PAX5
ENCSR000DIH
r=-0.00

small heat map img
10,000 randomly-selected peaks from a total of 16,619 (download )

Notes

Peaks (left to right in the heatmap) are sorted by the descending order of [-log10(q-value), -log10(p-value), TF ChIP-seq signal].

legend
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