FOSL1

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. RefSeq, Jul 2014
Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene.wikipedia

FOSL1


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Wikipedia FOSL1

Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks

C2C12 - Wold - ENCSR000AIK

loading

Legend

Proximal:
  • H3K27ac
  • H3K27me3
  • H3K36me3
  • H3K4me1
  • H3K4me2
  • H3K4me3
  • H3K79me2
  • H3K79me3
  • H3K9ac
  • H3K9me3
  • H3ac
Distal:
  • H3K27ac
  • H3K27me3
  • H3K36me3
  • H3K4me1
  • H3K4me2
  • H3K4me3
  • H3K79me2
  • H3K79me3
  • H3K9ac
  • H3K9me3
  • H3ac

Notes

Average histone modification profiles are shown for the [-2 kb, +2 kb] window around the summits of TF ChIP-seq peaks. Profile are shown separately for peaks that are proximal ([-1 kb, +1 kb]; ending in '-p') to an annotated transcript start site (TSS) and for peaks that are distal (>1 kb; ending in '-d') to all annotated TSS. TSS-proximal profiles are arranged such that the nearest transcript proceeds towards the right.

Motifs Enriched in the Top 500 ChIP-seq Peaks

C2C12 - Wold - ENCSR000AIK

1.
449 / 500
6.9e-632
GATGAGTCACT
small heat map img p-value: 0.00
pct_center: 0.84
pct_ratio: 5.06
2.
251 / 500
3.8e-122
TGAGTCAT
small heat map img p-value: 0.00
pct_center: 0.82
pct_ratio: 4.58
3.
57 / 500
0.0067
TGTGGTTT
small heat map img p-value: 0.00
pct_center: 0.21
pct_ratio: 0.97
4.
56 / 500
1.2e+2
ACAGGAAG
small heat map img p-value: 0.01
pct_center: 0.22
pct_ratio: 0.62
5.
19 / 500
1.8e+3
GGGGCTGGGGG
small heat map img p-value: 0.94
pct_center: 0.17
pct_ratio: 0.44
MEME output

Notes

The top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Up to five motifs are reported (1 to 5) if they meet the criteria defined by our pipeline.

Binding of other histone marks at FOSL1 peaks

C2C12 - Wold - ENCSR000AIK

C2C12
Wold
FOSL1
ENCSR000AIK
r=1.00

small heat map img

C2C12
Wold
H3ac
ENCSR000AHP
r=0.15

small heat map img

C2C12
Wold
H3K4me3
ENCSR000AHO
r=0.06

small heat map img

C2C12
Wold
H3K79me2
ENCSR000AHQ
r=-0.02

small heat map img

C2C12
Wold
H3K79me3
ENCSR000AHW
r=-0.02

small heat map img

C2C12
Wold
H3K36me3
ENCSR000AHL
r=-0.04

small heat map img

C2C12
Wold
H3K27me3
ENCSR000AHR
r=-0.05

small heat map img
6,496 peaks (download )

Notes

ChIP-seq peaks (left to right in the heatmap) for the current TF are sorted by descending TF ChIP-seq signal. The ChIP-seq signals of histone modifications are plotted for the genomic regions that correspond to the peaks of the current TF in the same order. The Pearson correlation coefficient (r) of the histone modification ChIP-seq signal with the TF ChIP-seq signal is shown.

legend
Binding of other TFs at FOSL1 peaks

C2C12 - Wold - ENCSR000AIK

C2C12
Wold
FOSL1
ENCSR000AIK
r=1.00

small heat map img

C2C12
Wold
MAX
ENCSR000AIO
r=0.52

small heat map img

C2C12
Wold
MYOD1
ENCSR000AIG
r=0.46

small heat map img

C2C12
Wold
CEBPB
ENCSR000AIV
r=0.42

small heat map img

C2C12
Wold
USF1
ENCSR000AIQ
r=0.31

small heat map img

C2C12
Wold
MYOG
ENCSR000AIF
r=0.06

small heat map img

C2C12
Wold
CTCF
ENCSR000AIJ
r=0.05

small heat map img
6,496 peaks (download )

Notes

Peaks (left to right in the heatmap) are sorted by the descending order of [-log10(q-value), -log10(p-value), TF ChIP-seq signal].

legend
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