SREBP2

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sterol regulatory element binding transcription factor 2
SREBP2

PDB ID : 1UKL
PDB1UKL
HGNC(alias)SREBF2 (bHLHd2,SREBP2)
Gene CardSREBF2
Entrez6721
RefSeqNM_004599
UniProtQ12772
UCSCBrowser view
WikipediaSREBF2
Protein FamilyHLH, helix-loop-helix DNA-binding domain
TypePol II TF
Ensembl Exp.Human

Function

SREBP2 (sterol regulatory element binding protein 2) is a transcriptional activator that binds the sterol regulatory element 1 (SRE-1) sequence 5'-ATCACCCCAC-3' found in the flanking region of the LDRL and HMG-CoA synthase genes. It controls lipid homeostasis by stimulating transcription of sterol-regulated genes. SREBP2 contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.

ENCODE ChIP-seq Datasets

No Available Data

Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks

No Available Data

Average Profiles of Nucleosomes around the Summit of ChIP-seq Peaks

No Available Data

Motifs Enriched in the Top 500 ChIP-seq Peaks

The sequences of the top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Five motifs are reported (M1 to M5), with motif name, sequence logo, and number of peaks out of the top 500 peaks that contain a site for the motif. The motifs are then used to scan the entire set of ChIP-seq peaks and the two flanking (control) regions using the FIMO tool, and two quantities are reported for bins of peaks sorted by their ChIP-seq q-values: percentage of the peaks that contain a site for the motif, and the distribution of the distances of the motif site to the summit of the peak.

Select MotifCell Line:   Lab:   Protocol:   Treatment:   Antibody:  



Binding of Other Transcription Factors or Histone Marks at the SREBP2 Peaks

Select HeatmapLab:   Cellline:  

  • Comparison with the SREBP2 peaks in HEPG2 cells generated by SYDH