IRF4

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interferon regulatory factor 4
IRF4

PDB ID : 2DLL
PDB2DLL
HGNC(alias)IRF4 (MUM1,LSIRF)
Gene CardIRF4
Entrez3662
RefSeqNM_001195286
UniProtQ15306
UCSCBrowser view
WikipediaIRF4
Protein FamilyWinged helix DNA-binding domain
TypePol II TF
Ensembl Exp.Human

Function

IRF4 (interferon regulatory factor 4) belongs to the IRF family of transcription factors, characterized by a unique tryptophan pentad repeat DNA-binding domain. IRFs play an important role in regulating interferons in response to viral infection, and the regulation of interferon-inducible genes as well. IRF4 is lymphocyte-specific, and is a negative regulator of Toll-like-receptor (TLR) signaling central to the activation of innate and adaptive immune systems. IRF4 binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter, and likely plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. It binds the immunoglobulin lambda light chain enhancer, together with PU.1. A chromosomal translocation involving IRF4 and the IgH locus may be a cause of multiple myeloma.

ENCODE ChIP-seq Datasets

No Available Data

Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks

No Available Data

Average Profiles of Nucleosomes around the Summit of ChIP-seq Peaks

No Available Data

Motifs Enriched in the Top 500 ChIP-seq Peaks

The sequences of the top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Five motifs are reported (M1 to M5), with motif name, sequence logo, and number of peaks out of the top 500 peaks that contain a site for the motif. The motifs are then used to scan the entire set of ChIP-seq peaks and the two flanking (control) regions using the FIMO tool, and two quantities are reported for bins of peaks sorted by their ChIP-seq q-values: percentage of the peaks that contain a site for the motif, and the distribution of the distances of the motif site to the summit of the peak.

Select MotifCell Line:   Lab:   Protocol:   Treatment:   Antibody:  



Binding of Other Transcription Factors or Histone Marks at the IRF4 Peaks

Select HeatmapLab:   Cellline:  

  • Comparison with the IRF4 peaks in GM12878 cells generated by HAIB