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hairy/enhancer-of-split related with YRPW motif 1

Gene CardHEY1
UCSCBrowser view
Protein FamilyHLH, helix-loop-helix DNA-binding domain
TypePol II TF
Ensembl Exp.Human


HEY1 is a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. It binds to the canonical E-box sequence 5'-CACGTG-3'. HEY1 expression is induced by the Notch and c-Jun signal transduction pathways. It may be required for embryonic cardiovascular development, neurogenesis, and somitogenesis. Alternative splicing results in multiple transcript variants.

ENCODE ChIP-seq Datasets

No Available Data

Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks

No Available Data

Average Profiles of Nucleosomes around the Summit of ChIP-seq Peaks

No Available Data

Motifs Enriched in the Top 500 ChIP-seq Peaks

The sequences of the top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Five motifs are reported (M1 to M5), with motif name, sequence logo, and number of peaks out of the top 500 peaks that contain a site for the motif. The motifs are then used to scan the entire set of ChIP-seq peaks and the two flanking (control) regions using the FIMO tool, and two quantities are reported for bins of peaks sorted by their ChIP-seq q-values: percentage of the peaks that contain a site for the motif, and the distribution of the distances of the motif site to the summit of the peak.

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Binding of Other Transcription Factors or Histone Marks at the HEY1 Peaks

No Available Data