HEY1
From FactorBook
hairy/enhancer-of-split related with YRPW motif 1
| HEY1 | |||
|---|---|---|---|
 PDB ID : 2DB7 | |||
| PDB | 2DB7 | ||
| HGNC(alias) | HEY1 (CHF2,CHF-2,HESR-1,HRT-1,BHLHb31,HESR1,HERP2) | ||
| Gene Card | HEY1 | ||
| Entrez | 23462 | ||
| RefSeq | NM_001040708 | ||
| UniProt | Q9Y5J3 | ||
| UCSC | Browser view | ||
| Wikipedia | HEY1 | ||
| Protein Family | HLH, helix-loop-helix DNA-binding domain | ||
| Type | Pol II TF | ||
| Ensembl Exp. | Human | ||
Function
HEY1 is a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. It binds to the canonical E-box sequence 5'-CACGTG-3'. HEY1 expression is induced by the Notch and c-Jun signal transduction pathways. It may be required for embryonic cardiovascular development, neurogenesis, and somitogenesis. Alternative splicing results in multiple transcript variants.
ENCODE ChIP-seq Datasets
No Available Data
Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks
No Available Data
Average Profiles of Nucleosomes around the Summit of ChIP-seq Peaks
No Available Data
Motifs Enriched in the Top 500 ChIP-seq Peaks
The sequences of the top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Five motifs are reported (M1 to M5), with motif name, sequence logo, and number of peaks out of the top 500 peaks that contain a site for the motif. The motifs are then used to scan the entire set of ChIP-seq peaks and the two flanking (control) regions using the FIMO tool, and two quantities are reported for bins of peaks sorted by their ChIP-seq q-values: percentage of the peaks that contain a site for the motif, and the distribution of the distances of the motif site to the summit of the peak.
Binding of Other Transcription Factors or Histone Marks at the HEY1 Peaks
No Available Data
