forkhead box P2
PDB ID : 2AS5
|Protein Family||Winged helix DNA-binding domain|
|Type||Pol II TF|
FOXP2 (forehead box protein P2) is a member of the forkhead/winged-helix (FOX) family of transcription factors and contains a FOX DNA-binding domain and a large polyglutamine tract. It is a transcriptional repressor expressed in fetal and adult brains, and is required for proper speech, language, lung, and gut development. FOXP2 mutations cause SPCH1, a severe speech and language disorder (also known as autosomal dominant speech and language disorder with developmental verbal dyspraxia).
ENCODE ChIP-seq Datasets
Indicated in the matrix are the numbers of datasets specified by lab and cell line; when the number is greater than 1, multiple ChIP-seq experiments have been performed, some upon treatments. Click the numbers to download the data files on ChIP-seq peaks, alignments, etc.
Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks
No Available Data
Average Profiles of Nucleosomes around the Summit of ChIP-seq Peaks
No Available Data
Motifs Enriched in the Top 500 ChIP-seq Peaks
The sequences of the top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Five motifs are reported (M1 to M5), with motif name, sequence logo, and number of peaks out of the top 500 peaks that contain a site for the motif. The motifs are then used to scan the entire set of ChIP-seq peaks and the two flanking (control) regions using the FIMO tool, and two quantities are reported for bins of peaks sorted by their ChIP-seq q-values: percentage of the peaks that contain a site for the motif, and the distribution of the distances of the motif site to the summit of the peak.