FOXP2

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forkhead box P2
FOXP2

PDB ID : 2AS5
PDB2AS5 2A07
HGNC(alias)FOXP2 (SPCH1,CAGH44,TNRC10)
Gene CardFOXP2
Entrez93986
RefSeqNM_001172766
UniProtO15409
UCSCBrowser view
WikipediaFOXP2
Protein FamilyWinged helix DNA-binding domain
TypePol II TF
Ensembl Exp.Human

Function

FOXP2 (forehead box protein P2) is a member of the forkhead/winged-helix (FOX) family of transcription factors and contains a FOX DNA-binding domain and a large polyglutamine tract. It is a transcriptional repressor expressed in fetal and adult brains, and is required for proper speech, language, lung, and gut development. FOXP2 mutations cause SPCH1, a severe speech and language disorder (also known as autosomal dominant speech and language disorder with developmental verbal dyspraxia).

ENCODE ChIP-seq Datasets

Indicated in the matrix are the numbers of datasets specified by lab and cell line; when the number is greater than 1, multiple ChIP-seq experiments have been performed, some upon treatments. Click the numbers to download the data files on ChIP-seq peaks, alignments, etc.

+/-
HudsonAlpha
PFSK-1 1
SK-N-MC 1


Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks

No Available Data

Average Profiles of Nucleosomes around the Summit of ChIP-seq Peaks

No Available Data

Motifs Enriched in the Top 500 ChIP-seq Peaks

The sequences of the top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Five motifs are reported (M1 to M5), with motif name, sequence logo, and number of peaks out of the top 500 peaks that contain a site for the motif. The motifs are then used to scan the entire set of ChIP-seq peaks and the two flanking (control) regions using the FIMO tool, and two quantities are reported for bins of peaks sorted by their ChIP-seq q-values: percentage of the peaks that contain a site for the motif, and the distribution of the distances of the motif site to the summit of the peak.

Select MotifCell Line:   Lab:   Protocol:   Treatment:   Antibody:  



Binding of Other Transcription Factors or Histone Marks at the FOXP2 Peaks

Select HeatmapLab:   Cellline:  

  • Comparison with the FOXP2 peaks in PFSK1 cells generated by HAIB