The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.RefSeq, Dec 2013
Signal transducer and activator of transcription 5A is a protein that in humans is encoded by the STAT5A gene. STAT5A orthologs have been identified in several placentals for which complete genome data are available.wikipedia
Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks
GM12878 - Myers - ENCSR000BQZ

K562 - Myers - ENCSR000BRR

Legend
- H2AFZ
- H3K27ac
- H3K27me3
- H3K36me3
- H3K4me1
- H3K4me2
- H3K4me3
- H3K79me2
- H3K9ac
- H3K9me1
- H3K9me3
- H4K20me1
- H2AFZ
- H3K27ac
- H3K27me3
- H3K36me3
- H3K4me1
- H3K4me2
- H3K4me3
- H3K79me2
- H3K9ac
- H3K9me1
- H3K9me3
- H4K20me1
Notes
Average histone modification profiles are shown for the [-2 kb, +2 kb] window around the summits of TF ChIP-seq peaks. Profile are shown separately for peaks that are proximal ([-1 kb, +1 kb]; ending in '-p') to an annotated transcript start site (TSS) and for peaks that are distal (>1 kb; ending in '-d') to all annotated TSS. TSS-proximal profiles are arranged such that the nearest transcript proceeds towards the right.
Motifs Enriched in the Top 500 ChIP-seq Peaks
GM12878 - Myers - ENCSR000BQZ
MEME outputNotes
The top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Up to five motifs are reported (1 to 5) if they meet the criteria defined by our pipeline.
K562 - Myers - ENCSR000BRR
MEME outputNotes
The top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Up to five motifs are reported (1 to 5) if they meet the criteria defined by our pipeline.
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ChIP-seq peaks (left to right in the heatmap) for the current TF are sorted by descending TF ChIP-seq signal. The ChIP-seq signals of histone modifications are plotted for the genomic regions that correspond to the peaks of the current TF in the same order. The Pearson correlation coefficient (r) of the histone modification ChIP-seq signal with the TF ChIP-seq signal is shown.

GM12878 - Myers - ENCSR000BQZ
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K562 - Myers - ENCSR000BRR
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Notes
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Average Profiles of Nucleosomes around the Summit of ChIP-seq Peaks
GM12878 - Myers - ENCSR000BQZ

K562 - Myers - ENCSR000BRR

Notes
Average nucleosome occupancy profiles in GM12878 and K562 cells are shown for the [-2 kb, +2 kb] window centered on the summits of the TF ChIP-seq peaks, separately for peaks that are proximal to an annotated transcription start site (red lines) and for peaks that are distal to all annotated transcription start sites (blue lines), as defined in the Histone section.