NR3C1 - Factorbook

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). RefSeq, Feb 2011

The glucocorticoid receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response.wikipedia

NR3C1
PDB 1M2Z
PDB	1M2Z 1NHZ 1P93 3BQD 3CLD 3E7C 3H52 3K22 3K23 4CSJ 4HN5 4HN6 4LSJ 4MDD 4P6W 4P6X
ENCODE	experiments
Ensemble	search
Entrez	2908
GO	search
Gene Card	search
HGNC	search
RefSeq	search
UCSC	browse
UniProt	search
Wikipedia	NR3C1

Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks

A549 - Myers - ENCSR000BHE

A549 - Myers - ENCSR000BHF

A549 - Myers - ENCSR000BHG

A549 - Myers - ENCSR000BJR

HepG2 - Snyder - ENCSR000EEV

Legend

Proximal:

H2AFZ
H3K27ac
H3K27me3
H3K36me3
H3K4me1
H3K4me2
H3K4me3
H3K79me2
H3K9ac
H3K9me1
H3K9me3
H4K20me1

Distal:

H2AFZ
H3K27ac
H3K27me3
H3K36me3
H3K4me1
H3K4me2
H3K4me3
H3K79me2
H3K9ac
H3K9me1
H3K9me3
H4K20me1

Notes

Average histone modification profiles are shown for the [-2 kb, +2 kb] window around the summits of TF ChIP-seq peaks. Profile are shown separately for peaks that are proximal ([-1 kb, +1 kb]; ending in '-p') to an annotated transcript start site (TSS) and for peaks that are distal (>1 kb; ending in '-d') to all annotated TSS. TSS-proximal profiles are arranged such that the nearest transcript proceeds towards the right.

Motifs Enriched in the Top 500 ChIP-seq Peaks

A549 - Myers - ENCSR000BJR

1. 418 / 500 2.5e-536 GGAACAGGATGTCCT		p-value: 0.00 pct_center: 0.39 pct_ratio: 2.35
2. 161 / 500 1.9e-31 GGGGAGGGGGCAGGG		p-value: 0.22 pct_center: 0.58 pct_ratio: 0.57
3. 51 / 500 4.4e-13 CTGAGTCA		p-value: 0.00 pct_center: 0.17 pct_ratio: 1.47
4. 56 / 500 0.00030 CTGGAACA		p-value: 0.00 pct_center: 0.22 pct_ratio: 0.90
5. 40 / 500 0.00047 CTGTGTGCACAGTG		p-value: 0.00 pct_center: 0.16 pct_ratio: 0.71

MEME output

A549 - Myers - ENCSR000BHF

1. 500 / 500 2.3e-653 GGAACAGAATGTTCT		p-value: 0.00 pct_center: 0.46 pct_ratio: 3.00
2. 80 / 500 7.9e-46 ATGAGTCA		p-value: 0.00 pct_center: 0.26 pct_ratio: 1.90
3. 95 / 500 1.0e-13 CAGGAACA		p-value: 0.00 pct_center: 0.26 pct_ratio: 0.85
4. 37 / 500 1.7e-11 TGAGGGGGGGGGGGGGAGGAG		p-value: 0.41 pct_center: 0.34 pct_ratio: 0.56
5. 66 / 500 0.022 CAGGACAG		p-value: 0.00 pct_center: 0.29 pct_ratio: 0.67

MEME output

A549 - Myers - ENCSR000BHG

1. 444 / 500 2.4e-604 AAAGAACAGAATGTTCT		p-value: 0.00 pct_center: 0.42 pct_ratio: 2.92
2. 109 / 500 3.6e-44 ATGAGTCA		p-value: 0.00 pct_center: 0.34 pct_ratio: 1.89
3. 60 / 500 0.0012 GGGGAGAGGGAGGGG		p-value: 0.00 pct_center: 0.34 pct_ratio: 0.57
4. 55 / 500 7.3 CTGTTTGCACAGTGA		p-value: 0.00 pct_center: 0.19 pct_ratio: 0.80
5. 9 / 500 2.9e+2 GCCCTGGAGACAGGCTGGTGC		p-value: 0.90 pct_center: 0.20 pct_ratio: 0.54

MEME output