This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing resultsi n multiple transcript variants.RefSeq, Sep 2015
Lysine-specific demethylase 5B also known as histone demethylase JARID1B is a demethylase enzyme that in humans is encoded by the KDM5B gene.wikipedia
Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks
H1-hESC - Bernstein - ENCSR000AUR

K562 - Bernstein - ENCSR000AQA

Legend
- H2AFZ
- H3K27ac
- H3K27me3
- H3K36me3
- H3K4me1
- H3K4me2
- H3K4me3
- H3K79me2
- H3K9ac
- H3K9me1
- H3K9me3
- H4K20me1
- H2AFZ
- H3K27ac
- H3K27me3
- H3K36me3
- H3K4me1
- H3K4me2
- H3K4me3
- H3K79me2
- H3K9ac
- H3K9me1
- H3K9me3
- H4K20me1
Notes
Average histone modification profiles are shown for the [-2 kb, +2 kb] window around the summits of TF ChIP-seq peaks. Profile are shown separately for peaks that are proximal ([-1 kb, +1 kb]; ending in '-p') to an annotated transcript start site (TSS) and for peaks that are distal (>1 kb; ending in '-d') to all annotated TSS. TSS-proximal profiles are arranged such that the nearest transcript proceeds towards the right.
Motifs Enriched in the Top 500 ChIP-seq Peaks
H1-hESC - Bernstein - ENCSR000AUR
MEME outputNotes
The top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Up to five motifs are reported (1 to 5) if they meet the criteria defined by our pipeline.
K562 - Bernstein - ENCSR000AQA
MEME outputNotes
The top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Up to five motifs are reported (1 to 5) if they meet the criteria defined by our pipeline.
H1-hESC - Bernstein - ENCSR000AUR
H1-hESC |
![]() |
---|---|
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
K562 - Bernstein - ENCSR000AQA
K562 |
|
---|---|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
Notes
ChIP-seq peaks (left to right in the heatmap) for the current TF are sorted by descending TF ChIP-seq signal. The ChIP-seq signals of histone modifications are plotted for the genomic regions that correspond to the peaks of the current TF in the same order. The Pearson correlation coefficient (r) of the histone modification ChIP-seq signal with the TF ChIP-seq signal is shown.

H1-hESC - Bernstein - ENCSR000AUR
H1-hESC |
![]() |
---|---|
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
K562 - Bernstein - ENCSR000AQA
K562 |
|
---|---|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
K562 |
|
Notes
Peaks (left to right in the heatmap) are sorted by the descending order of [-log10(q-value), -log10(p-value), TF ChIP-seq signal].

Average Profiles of Nucleosomes around the Summit of ChIP-seq Peaks
K562 - Bernstein - ENCSR000AQA

Notes
Average nucleosome occupancy profiles in GM12878 and K562 cells are shown for the [-2 kb, +2 kb] window centered on the summits of the TF ChIP-seq peaks, separately for peaks that are proximal to an annotated transcription start site (red lines) and for peaks that are distal to all annotated transcription start sites (blue lines), as defined in the Histone section.