IKZF1

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). RefSeq, May 2014
DNA-binding protein Ikaros also known as Ikaros family zinc finger protein 1 is a protein that in humans is encoded by the IKZF1 gene. Ikaros displays crucial functions in the hematopoietic system and its loss of function has been linked to the development of lymphoid leukemia.wikipedia

IKZF1


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Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks

GM12878 - Farnham - ENCSR000EUJ

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Legend

Proximal:
  • H2AFZ
  • H3K27ac
  • H3K27me3
  • H3K36me3
  • H3K4me1
  • H3K4me2
  • H3K4me3
  • H3K79me2
  • H3K9ac
  • H3K9me1
  • H3K9me3
  • H4K20me1
Distal:
  • H2AFZ
  • H3K27ac
  • H3K27me3
  • H3K36me3
  • H3K4me1
  • H3K4me2
  • H3K4me3
  • H3K79me2
  • H3K9ac
  • H3K9me1
  • H3K9me3
  • H4K20me1

Notes

Average histone modification profiles are shown for the [-2 kb, +2 kb] window around the summits of TF ChIP-seq peaks. Profile are shown separately for peaks that are proximal ([-1 kb, +1 kb]; ending in '-p') to an annotated transcript start site (TSS) and for peaks that are distal (>1 kb; ending in '-d') to all annotated TSS. TSS-proximal profiles are arranged such that the nearest transcript proceeds towards the right.

Motifs Enriched in the Top 500 ChIP-seq Peaks

GM12878 - Farnham - ENCSR000EUJ

1.
266 / 500
7.4e-140
AGGGGAAGAGAAAGTGAAAGA
small heat map img p-value: 0.00
pct_center: 0.54
pct_ratio: 0.61
2.
137 / 500
3.5e-33
CTGTGGTT
small heat map img p-value: 0.00
pct_center: 0.26
pct_ratio: 0.97
3.
142 / 500
5.3e-7
AGGAAG
small heat map img p-value: 0.00
pct_center:
pct_ratio:
4.
32 / 500
0.048
AATGACTCAGA
small heat map img p-value: 0.00
pct_center: 0.18
pct_ratio: 0.76
5.
25 / 500
78
CCTGGGCTGGA
small heat map img p-value: 0.29
pct_center: 0.19
pct_ratio: 0.52
MEME output

Notes

The top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Up to five motifs are reported (1 to 5) if they meet the criteria defined by our pipeline.

Binding of other histone marks at IKZF1 peaks

GM12878 - Farnham - ENCSR000EUJ

GM12878
Farnham
IKZF1
ENCSR000EUJ
r=1.00

small heat map img

GM12878
Farnham
H3K27ac
ENCSR000AKC
r=0.41

small heat map img

GM12878
Farnham
H3K4me2
ENCSR000AKG
r=0.41

small heat map img

GM12878
Farnham
H3K4me1
ENCSR000AKF
r=0.40

small heat map img

GM12878
Farnham
H3K4me3
ENCSR000AKA
r=0.35

small heat map img

GM12878
Farnham
H3K9ac
ENCSR000AKH
r=0.32

small heat map img

GM12878
Farnham
H2AFZ
ENCSR000AOV
r=0.30

small heat map img

GM12878
Farnham
H3K4me3
ENCSR000DRY
r=0.16

small heat map img

GM12878
Farnham
H3K79me2
ENCSR000AOW
r=0.10

small heat map img

GM12878
Farnham
H3K9me3
ENCSR000AOX
r=0.01

small heat map img

GM12878
Farnham
H4K20me1
ENCSR000AKI
r=0.01

small heat map img

GM12878
Farnham
H3K36me3
ENCSR000DRW
r=-0.01

small heat map img

GM12878
Farnham
H3K36me3
ENCSR000AKE
r=-0.02

small heat map img

GM12878
Farnham
H3K27me3
ENCSR000DRX
r=-0.05

small heat map img

GM12878
Farnham
H3K27me3
ENCSR000AKD
r=-0.07

small heat map img
9,047 peaks (download )

Notes

ChIP-seq peaks (left to right in the heatmap) for the current TF are sorted by descending TF ChIP-seq signal. The ChIP-seq signals of histone modifications are plotted for the genomic regions that correspond to the peaks of the current TF in the same order. The Pearson correlation coefficient (r) of the histone modification ChIP-seq signal with the TF ChIP-seq signal is shown.

legend
Binding of other TFs at IKZF1 peaks

GM12878 - Farnham - ENCSR000EUJ

GM12878
Farnham
IKZF1
ENCSR000EUJ
r=1.00

small heat map img

GM12878
Farnham
EP300
ENCSR000DZG
r=0.78

small heat map img

GM12878
Farnham
TBL1XR1
ENCSR000DYZ
r=0.78

small heat map img

GM12878
Farnham
EP300
ENCSR000DZD
r=0.76

small heat map img

GM12878
Farnham
RCOR1
ENCSR000DZC
r=0.75

small heat map img

GM12878
Farnham
STAT3
ENCSR000DZV
r=0.75

small heat map img

GM12878
Farnham
RELA
ENCSR000EAG
r=0.74

small heat map img

GM12878
Farnham
RUNX3
ENCSR000BRI
r=0.73

small heat map img

GM12878
Farnham
SMC3
ENCSR000DZP
r=0.70

small heat map img

GM12878
Farnham
NFIC
ENCSR000BRN
r=0.70

small heat map img

GM12878
Farnham
CUX1
ENCSR000DYR
r=0.70

small heat map img

GM12878
Farnham
BHLHE40
ENCSR000DZJ
r=0.69

small heat map img

GM12878
Farnham
MXI1
ENCSR000DZI
r=0.69

small heat map img

GM12878
Farnham
FOXM1
ENCSR000BRU
r=0.67

small heat map img

GM12878
Farnham
ATF2
ENCSR000BQK
r=0.66

small heat map img

GM12878
Farnham
MAX
ENCSR000DZF
r=0.64

small heat map img

GM12878
Farnham
STAT1
ENCSR000DZM
r=0.63

small heat map img

GM12878
Farnham
ELK1
ENCSR000DZB
r=0.63

small heat map img

GM12878
Farnham
RAD21
ENCSR000EAC
r=0.63

small heat map img

GM12878
Farnham
JUND
ENCSR000DYS
r=0.62

small heat map img

GM12878
Farnham
CREB1
ENCSR000BUF
r=0.62

small heat map img

GM12878
Farnham
CEBPB
ENCSR000BRX
r=0.59

small heat map img

GM12878
Farnham
CHD1
ENCSR000DZE
r=0.59

small heat map img

GM12878
Farnham
ESRRA
ENCSR000DYQ
r=0.58

small heat map img

GM12878
Farnham
SP1
ENCSR000BHK
r=0.57

small heat map img

GM12878
Farnham
JUND
ENCSR000EYV
r=0.56

small heat map img

GM12878
Farnham
SREBF1
ENCSR000DYU
r=0.55

small heat map img

GM12878
Farnham
RFX5
ENCSR000DZW
r=0.55

small heat map img

GM12878
Farnham
BCL3
ENCSR000BNQ
r=0.53

small heat map img

GM12878
Farnham
WRNIP1
ENCSR000EAA
r=0.52

small heat map img

GM12878
Farnham
USF2
ENCSR000DZU
r=0.52

small heat map img

GM12878
Farnham
BCL11A
ENCSR000BHA
r=0.51

small heat map img

GM12878
Farnham
NFATC1
ENCSR000BQL
r=0.51

small heat map img

GM12878
Farnham
MAFK
ENCSR000DYV
r=0.51

small heat map img

GM12878
Farnham
NRF1
ENCSR000DZO
r=0.51

small heat map img

GM12878
Farnham
SIN3A
ENCSR000DYX
r=0.51

small heat map img

GM12878
Farnham
TBP
ENCSR000DZZ
r=0.50

small heat map img

GM12878
Farnham
MEF2A
ENCSR000BKB
r=0.50

small heat map img

GM12878
Farnham
EBF1
ENCSR000DZQ
r=0.50

small heat map img

GM12878
Farnham
EZH2
ENCSR000ARD
r=0.50

small heat map img

GM12878
Farnham
ZNF143
ENCSR000DZL
r=0.50

small heat map img

GM12878
Farnham
MTA3
ENCSR000BRH
r=0.50

small heat map img

GM12878
Farnham
PAX5
ENCSR000BHD
r=0.49

small heat map img

GM12878
Farnham
IRF3
ENCSR000DZX
r=0.49

small heat map img

GM12878
Farnham
BRCA1
ENCSR000DZS
r=0.48

small heat map img

GM12878
Farnham
TCF12
ENCSR000BGZ
r=0.48

small heat map img

GM12878
Farnham
BATF
ENCSR000BGT
r=0.48

small heat map img

GM12878
Farnham
ZNF384
ENCSR000DYP
r=0.48

small heat map img

GM12878
Farnham
STAT5A
ENCSR000BQZ
r=0.47

small heat map img

GM12878
Farnham
IRF4
ENCSR000BGY
r=0.47

small heat map img

GM12878
Farnham
SREBF2
ENCSR000DYT
r=0.47

small heat map img

GM12878
Farnham
PML
ENCSR000BQM
r=0.47

small heat map img

GM12878
Farnham
E2F4
ENCSR000DYY
r=0.45

small heat map img

GM12878
Farnham
EP300
ENCSR000BHB
r=0.44

small heat map img

GM12878
Farnham
NFE2
ENCSR000DZY
r=0.44

small heat map img

GM12878
Farnham
EBF1
ENCSR000BGU
r=0.44

small heat map img

GM12878
Farnham
FOS
ENCSR000EYZ
r=0.43

small heat map img

GM12878
Farnham
POLR2A
ENCSR000EAD
r=0.43

small heat map img

GM12878
Farnham
NFYB
ENCSR000DNM
r=0.42

small heat map img

GM12878
Farnham
YY1
ENCSR000EUM
r=0.42

small heat map img

GM12878
Farnham
TCF3
ENCSR000BQT
r=0.42

small heat map img

GM12878
Farnham
PAX5
ENCSR000BHJ
r=0.41

small heat map img

GM12878
Farnham
ELF1
ENCSR000BMB
r=0.39

small heat map img

GM12878
Farnham
POU2F2
ENCSR000BGP
r=0.39

small heat map img

GM12878
Farnham
POLR2A
ENCSR000DKT
r=0.38

small heat map img

GM12878
Farnham
SPI1
ENCSR000BGQ
r=0.37

small heat map img

GM12878
Farnham
POLR2A
ENCSR000EYW
r=0.36

small heat map img

GM12878
Farnham
ETS1
ENCSR000BKA
r=0.35

small heat map img

GM12878
Farnham
YY1
ENCSR000BNP
r=0.34

small heat map img

GM12878
Farnham
MYC
ENCSR000DKU
r=0.33

small heat map img

GM12878
Farnham
SUPT20H
ENCSR000DNP
r=0.32

small heat map img

GM12878
Farnham
NFYA
ENCSR000DNN
r=0.32

small heat map img

GM12878
Farnham
CTCF
ENCSR000DZN
r=0.30

small heat map img

GM12878
Farnham
KAT2A
ENCSR000DNO
r=0.30

small heat map img

GM12878
Farnham
SRF
ENCSR000BMI
r=0.30

small heat map img

GM12878
Farnham
EGR1
ENCSR000BMQ
r=0.23

small heat map img

GM12878
Farnham
RXRA
ENCSR000BJD
r=0.23

small heat map img

GM12878
Farnham
SIX5
ENCSR000BJE
r=0.21

small heat map img

GM12878
Farnham
CTCF
ENCSR000DKV
r=0.21

small heat map img

GM12878
Farnham
POLR2A
ENCSR000BGD
r=0.19

small heat map img

GM12878
Farnham
CTCF
ENCSR000AKB
r=0.19

small heat map img

GM12878
Farnham
RAD21
ENCSR000BMY
r=0.19

small heat map img

GM12878
Farnham
NR2C2
ENCSR000EUL
r=0.17

small heat map img

GM12878
Farnham
TAF1
ENCSR000BGS
r=0.17

small heat map img

GM12878
Farnham
MEF2C
ENCSR000BNG
r=0.17

small heat map img

GM12878
Farnham
PBX3
ENCSR000BGR
r=0.17

small heat map img

GM12878
Farnham
POLR3G
ENCSR000EYU
r=0.15

small heat map img

GM12878
Farnham
CTCF
ENCSR000DRZ
r=0.11

small heat map img

GM12878
Farnham
ZBTB33
ENCSR000BHC
r=0.10

small heat map img

GM12878
Farnham
ZEB1
ENCSR000BND
r=0.09

small heat map img

GM12878
Farnham
ATF3
ENCSR000BJY
r=0.09

small heat map img

GM12878
Farnham
USF1
ENCSR000BGI
r=0.07

small heat map img

GM12878
Farnham
REST
ENCSR000BQS
r=0.06

small heat map img

GM12878
Farnham
ZNF274
ENCSR000EUK
r=0.06

small heat map img

GM12878
Farnham
EGR1
ENCSR000BRG
r=0.06

small heat map img

GM12878
Farnham
GABPA
ENCSR000BGC
r=0.05

small heat map img

GM12878
Farnham
ZZZ3
ENCSR000DNQ
r=0.05

small heat map img

GM12878
Farnham
SRF
ENCSR000BGE
r=0.04

small heat map img

GM12878
Farnham
REST
ENCSR000BGF
r=0.02

small heat map img
9,047 peaks (download )

Notes

Peaks (left to right in the heatmap) are sorted by the descending order of [-log10(q-value), -log10(p-value), TF ChIP-seq signal].

legend

Average Profiles of Nucleosomes around the Summit of ChIP-seq Peaks

GM12878 - Farnham - ENCSR000EUJ

loading

Notes

Average nucleosome occupancy profiles in GM12878 and K562 cells are shown for the [-2 kb, +2 kb] window centered on the summits of the TF ChIP-seq peaks, separately for peaks that are proximal to an annotated transcription start site (red lines) and for peaks that are distal to all annotated transcription start sites (blue lines), as defined in the Histone section.

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