This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14.RefSeq, Mar 2012
ETS domain-containing protein Elk-1 is a protein that in humans is encoded by the ELK1 gene. Elk-1 functions as a transcription activator.wikipedia
Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks
Legend
- H2AFZ
- H3K27ac
- H3K27me3
- H3K36me3
- H3K4me1
- H3K4me2
- H3K4me3
- H3K79me2
- H3K9ac
- H3K9me1
- H3K9me3
- H4K20me1
- H2AFZ
- H3K27ac
- H3K27me3
- H3K36me3
- H3K4me1
- H3K4me2
- H3K4me3
- H3K79me2
- H3K9ac
- H3K9me1
- H3K9me3
- H4K20me1
Notes
Average histone modification profiles are shown for the [-2 kb, +2 kb] window around the summits of TF ChIP-seq peaks. Profile are shown separately for peaks that are proximal ([-1 kb, +1 kb]; ending in '-p') to an annotated transcript start site (TSS) and for peaks that are distal (>1 kb; ending in '-d') to all annotated TSS. TSS-proximal profiles are arranged such that the nearest transcript proceeds towards the right.
Motifs Enriched in the Top 500 ChIP-seq Peaks
GM12878 - Snyder - ENCSR000DZB
MEME outputNotes
The top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Up to five motifs are reported (1 to 5) if they meet the criteria defined by our pipeline.
HeLa-S3 - Snyder - ENCSR000ECI
MEME outputNotes
The top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Up to five motifs are reported (1 to 5) if they meet the criteria defined by our pipeline.
K562 - Snyder - ENCSR000EFU
MEME outputNotes
The top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Up to five motifs are reported (1 to 5) if they meet the criteria defined by our pipeline.
GM12878 - Snyder - ENCSR000DZB
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HeLa-S3 - Snyder - ENCSR000ECI
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Notes
ChIP-seq peaks (left to right in the heatmap) for the current TF are sorted by descending TF ChIP-seq signal. The ChIP-seq signals of histone modifications are plotted for the genomic regions that correspond to the peaks of the current TF in the same order. The Pearson correlation coefficient (r) of the histone modification ChIP-seq signal with the TF ChIP-seq signal is shown.

GM12878 - Snyder - ENCSR000DZB
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HeLa-S3 - Snyder - ENCSR000ECI
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K562 - Snyder - ENCSR000EFU
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Notes
Peaks (left to right in the heatmap) are sorted by the descending order of [-log10(q-value), -log10(p-value), TF ChIP-seq signal].

Average Profiles of Nucleosomes around the Summit of ChIP-seq Peaks
GM12878 - Snyder - ENCSR000DZB

K562 - Snyder - ENCSR000EFU

Notes
Average nucleosome occupancy profiles in GM12878 and K562 cells are shown for the [-2 kb, +2 kb] window centered on the summits of the TF ChIP-seq peaks, separately for peaks that are proximal to an annotated transcription start site (red lines) and for peaks that are distal to all annotated transcription start sites (blue lines), as defined in the Histone section.