E2F6 - Factorbook

This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants. RefSeq, May 2013

E2F is a group of genes that codifies a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a.wikipedia

E2F6

ENCODE	experiments
Ensemble	search
Entrez	1876
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Wikipedia	E2F

Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks

A549 - Myers - ENCSR000BTC

H1-hESC - Myers - ENCSR000BSI

HeLa-S3 - Farnham - ENCSR000EVK

K562 - Farnham - ENCSR000EWJ

K562 - Myers - ENCSR000BLI

Legend

Proximal:

H2AFZ
H3K27ac
H3K27me3
H3K36me3
H3K4me1
H3K4me2
H3K4me3
H3K79me2
H3K9ac
H3K9me1
H3K9me3
H4K20me1

Distal:

H2AFZ
H3K27ac
H3K27me3
H3K36me3
H3K4me1
H3K4me2
H3K4me3
H3K79me2
H3K9ac
H3K9me1
H3K9me3
H4K20me1

Notes

Average histone modification profiles are shown for the [-2 kb, +2 kb] window around the summits of TF ChIP-seq peaks. Profile are shown separately for peaks that are proximal ([-1 kb, +1 kb]; ending in '-p') to an annotated transcript start site (TSS) and for peaks that are distal (>1 kb; ending in '-d') to all annotated TSS. TSS-proximal profiles are arranged such that the nearest transcript proceeds towards the right.

Motifs Enriched in the Top 500 ChIP-seq Peaks

A549 - Myers - ENCSR000BTC

1. 81 / 500 1.5e-29 GAGAGCAAGAGGCACATGAGGGAGGAAAA		p-value: 0.00 pct_center: 0.47 pct_ratio: 0.51
2. 79 / 500 3.1e-10 GGCGGGGGGCGGGCGGGAGGGGGCGGGGCC		p-value: 0.00 pct_center: 0.92 pct_ratio: 0.69
3. 23 / 500 0.000069 TGGTAAGGGCTTCTGGGAACTTGGGTTT		p-value: 0.99 pct_center: 0.07 pct_ratio: 0.38
4. 40 / 500 0.018 GCGCAGGCGCA		p-value: 0.00 pct_center: 0.44 pct_ratio: 0.75
5. 11 / 500 76 TTATGGCTGCAAAGGATAAAGCTCTTTCT		p-value: 0.59 pct_center: 0.08 pct_ratio: 0.50

MEME output

Notes

The top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Up to five motifs are reported (1 to 5) if they meet the criteria defined by our pipeline.

H1-hESC - Myers - ENCSR000BSI

1. 44 / 500 7.3e-29 TGTTAATTTTTTTTTTAAAAT		p-value: 0.64 pct_center: 0.05 pct_ratio: 0.21
2. 109 / 500 2.3e-45 GGGGGCGGAGGCGGCGGGAGGGGGGGGGG		p-value: 0.00 pct_center: 0.82 pct_ratio: 0.75
3. 23 / 500 0.0000028 TAGAAAACAAAAATT		p-value: 0.01 pct_center: 0.07 pct_ratio: 0.24
4. 9 / 500 7.9 AATAATTTTCATAAAGAAGTC		p-value: 0.53 pct_center: 0.02 pct_ratio: 0.29
5. 8 / 500 1.6e+2 CAGCCAATCAGAGAGCGCAG		p-value: 0.59 pct_center: 0.11 pct_ratio: 0.54

MEME output

Notes

HeLa-S3 - Farnham - ENCSR000EVK

1. 287 / 500 9.8e-202 GGGGCGGGAAA		p-value: 0.00 pct_center: 0.51 pct_ratio: 0.73
2. 128 / 500 1.0e-32 AGCACGTG		p-value: 0.00 pct_center: 0.19 pct_ratio: 1.38
3. 46 / 500 1.2e-12 TGCGCATGCGCGGT		p-value: 0.00 pct_center: 0.48 pct_ratio: 0.80
4. 24 / 500 2.5e-7 CTCTGATTGGCTGG		p-value: 0.00 pct_center: 0.10 pct_ratio: 0.77
5. 10 / 500 2.6e+3 TTGTTTTGGT		p-value: 0.36 pct_center: 0.02 pct_ratio: 0.19

MEME output

Notes

K562 - Farnham - ENCSR000EWJ

1. 323 / 500 8.1e-202 GGGGCGGGAAG		p-value: 0.00 pct_center: 0.49 pct_ratio: 0.75
2. 242 / 500 6.4e-69 GGCACGTGGCC		p-value: 0.00 pct_center: 0.32 pct_ratio: 1.61
3. 56 / 500 3.6e-16 CGCGCATGCGCAGA		p-value: 0.00 pct_center: 0.37 pct_ratio: 0.87
4. 19 / 500 0.0000013 CGCTCTGATTGGCTG		p-value: 0.00 pct_center: 0.14 pct_ratio: 0.77
5. 22 / 500 1.1 GAGAAGAAAAA		p-value: 0.17 pct_center: 0.12 pct_ratio: 0.36

MEME output

Notes

K562 - Myers - ENCSR000BLI

1. 371 / 500 8.0e-244 GGGGCGGGAAG		p-value: 0.00 pct_center: 0.53 pct_ratio: 0.82
2. 150 / 500 1.9e-53 GCGCACGTGGC		p-value: 0.00 pct_center: 0.22 pct_ratio: 1.71
3. 23 / 500 3.3e-13 CGCGCTGATTGGCTG		p-value: 0.00 pct_center: 0.18 pct_ratio: 0.76
4. 42 / 500 5.4e-10 GCGCATGCGCA		p-value: 0.00 pct_center: 0.31 pct_ratio: 0.89
5. 22 / 500 1.7e+2 AGAGAAGAGCT		p-value: 0.86 pct_center: 0.09 pct_ratio: 0.42

MEME output

Notes

Binding of other histone marks at E2F6 peaks

A549 - Myers - ENCSR000BTC

A549 Myers E2F6 ENCSR000BTC r=1.00
A549 Myers H2AFZ ENCSR000AUG r=0.39
A549 Myers H2AFZ ENCSR000AUH r=0.38
A549 Myers H3K4me3 ENCSR000ASH r=0.35
A549 Myers H3K4me3 ENCSR000AST r=0.34
A549 Myers H3K4me2 ENCSR000AVI r=0.33
A549 Myers H3K27ac ENCSR000AVF r=0.33
A549 Myers H3K9ac ENCSR000ASV r=0.33
A549 Myers H3K4me3 ENCSR000DPD r=0.33
A549 Myers H3K4me2 ENCSR000ATO r=0.32
A549 Myers H3K27ac ENCSR000AUI r=0.30
A549 Myers H3K4me1 ENCSR000AUM r=0.13
A549 Myers H3K4me1 ENCSR000AVH r=0.13
A549 Myers H3K79me2 ENCSR000ATP r=0.07
A549 Myers H3K79me2 ENCSR000ASU r=0.07
A549 Myers H3K9me3 ENCSR000AUN r=0.06
A549 Myers H3K27me3 ENCSR000AUK r=0.01
A549 Myers H3K36me3 ENCSR000AUL r=-0.02
A549 Myers H3K36me3 ENCSR000AVG r=-0.02
A549 Myers H4K20me1 ENCSR000AUO r=-0.02
A549 Myers H3K27me3 ENCSR000AUJ r=-0.03

6,791 peaks (download )

H1-hESC - Myers - ENCSR000BSI

H1-hESC Myers E2F6 ENCSR000BSI r=1.00
H1-hESC Myers H3K4me2 ENCSR000ANC r=0.33
H1-hESC Myers H3K4me3 ENCSR000AMG r=0.30
H1-hESC Myers H2AFZ ENCSR000APX r=0.28
H1-hESC Myers H3K9ac ENCSR000AND r=0.27
H1-hESC Myers H3K4me1 ENCSR000ANA r=0.21
H1-hESC Myers H3K27ac ENCSR000ANP r=0.20
H1-hESC Myers H3K27me3 ENCSR000ALU r=0.16
H1-hESC Myers H4K20me1 ENCSR000AMH r=0.06
H1-hESC Myers H3K79me2 ENCSR000APY r=0.01
H1-hESC Myers H3K9me3 ENCSR000APZ r=0.00
H1-hESC Myers H3K36me3 ENCSR000ANB r=-0.05

10,000 randomly-selected peaks from a total of 12,733 (download )

HeLa-S3 - Farnham - ENCSR000EVK

HeLa-S3 Farnham E2F6 ENCSR000EVK r=1.00
HeLa-S3 Farnham H3K4me3 ENCSR000AOF r=0.49
HeLa-S3 Farnham H2AFZ ENCSR000AQN r=0.49
HeLa-S3 Farnham H3K9ac ENCSR000AOH r=0.48
HeLa-S3 Farnham H3K4me3 ENCSR000DUA r=0.46
HeLa-S3 Farnham H3K27ac ENCSR000AOC r=0.44
HeLa-S3 Farnham H3K4me2 ENCSR000AOE r=0.39
HeLa-S3 Farnham H3K4me1 ENCSR000APW r=0.13
HeLa-S3 Farnham H3K79me2 ENCSR000AOG r=0.09
HeLa-S3 Farnham H3K27me3 ENCSR000DTY r=0.06
HeLa-S3 Farnham H3K9me3 ENCSR000AQO r=-0.03
HeLa-S3 Farnham H4K20me1 ENCSR000AOI r=-0.05
HeLa-S3 Farnham H3K36me3 ENCSR000DTZ r=-0.06
HeLa-S3 Farnham H3K27me3 ENCSR000APB r=-0.06
HeLa-S3 Farnham H3K36me3 ENCSR000AOD r=-0.17

4,775 peaks (download )

K562 - Farnham - ENCSR000EWJ

K562 Farnham E2F6 ENCSR000EWJ r=1.00
K562 Farnham E2F6 ENCSR000BLI r=0.63
K562 Farnham H2AFZ ENCSR000APC r=0.41
K562 Farnham H3K9ac ENCSR000EVZ r=0.41
K562 Farnham H3K4me2 ENCSR000AKT r=0.40
K562 Farnham H3K4me3 ENCSR000AKU r=0.40
K562 Farnham H3K9ac ENCSR000AKV r=0.39
K562 Farnham H3K4me3 ENCSR000DWD r=0.38
K562 Farnham H3K27ac ENCSR000AKP r=0.36
K562 Farnham H3K4me3 ENCSR000EWA r=0.36
K562 Farnham H3K4me1 ENCSR000EWC r=0.25
K562 Farnham H3K79me2 ENCSR000APD r=0.16
K562 Farnham H3K4me1 ENCSR000AKS r=0.13
K562 Farnham H4K20me1 ENCSR000AKX r=0.07
K562 Farnham H3K9me1 ENCSR000AKW r=0.06
K562 Farnham H3K9me3 ENCSR000APE r=0.05
K562 Farnham H3K27me3 ENCSR000DWC r=0.01
K562 Farnham H3K27me3 ENCSR000AKQ r=0.01
K562 Farnham H3K36me3 ENCSR000AKR r=-0.02
K562 Farnham H3K36me3 ENCSR000DWB r=-0.03
K562 Farnham H3K27me3 ENCSR000EWB r=-0.05

10,000 randomly-selected peaks from a total of 16,312 (download )

K562 - Myers - ENCSR000BLI

K562 Myers E2F6 ENCSR000BLI r=1.00
K562 Myers E2F6 ENCSR000EWJ r=0.61
K562 Myers H2AFZ ENCSR000APC r=0.23
K562 Myers H3K9ac ENCSR000EVZ r=0.23
K562 Myers H3K4me3 ENCSR000AKU r=0.22
K562 Myers H3K9ac ENCSR000AKV r=0.22
K562 Myers H3K4me2 ENCSR000AKT r=0.22
K562 Myers H3K4me3 ENCSR000DWD r=0.21
K562 Myers H3K4me3 ENCSR000EWA r=0.20
K562 Myers H3K27ac ENCSR000AKP r=0.20
K562 Myers H3K4me1 ENCSR000EWC r=0.14
K562 Myers H3K79me2 ENCSR000APD r=0.10
K562 Myers H3K4me1 ENCSR000AKS r=0.08
K562 Myers H3K9me3 ENCSR000APE r=0.03
K562 Myers H4K20me1 ENCSR000AKX r=0.03
K562 Myers H3K9me1 ENCSR000AKW r=0.03
K562 Myers H3K36me3 ENCSR000AKR r=0.01
K562 Myers H3K27me3 ENCSR000DWC r=-0.01
K562 Myers H3K36me3 ENCSR000DWB r=-0.01
K562 Myers H3K27me3 ENCSR000AKQ r=-0.02
K562 Myers H3K27me3 ENCSR000EWB r=-0.06

10,000 randomly-selected peaks from a total of 24,570 (download )

Notes

ChIP-seq peaks (left to right in the heatmap) for the current TF are sorted by descending TF ChIP-seq signal. The ChIP-seq signals of histone modifications are plotted for the genomic regions that correspond to the peaks of the current TF in the same order. The Pearson correlation coefficient (r) of the histone modification ChIP-seq signal with the TF ChIP-seq signal is shown.

Binding of other TFs at E2F6 peaks

A549 - Myers - ENCSR000BTC

A549 Myers E2F6 ENCSR000BTC r=1.00
A549 Myers MAX ENCSR000BTJ r=0.77
A549 Myers MAX ENCSR000DYG r=0.73
A549 Myers MYC ENCSR000DYC r=0.56
A549 Myers SP1 ENCSR000BPE r=0.46
A549 Myers BHLHE40 ENCSR000DYJ r=0.44
A549 Myers CREB1 ENCSR000BRB r=0.42
A549 Myers POLR2A ENCSR000DMZ r=0.41
A549 Myers PBX3 ENCSR000BTN r=0.40
A549 Myers TEAD4 ENCSR000BUD r=0.40
A549 Myers POLR2A ENCSR000BHI r=0.39
A549 Myers GATA3 ENCSR000BTI r=0.39
A549 Myers POLR2A ENCSR000BHH r=0.38
A549 Myers TAF1 ENCSR000BPF r=0.38
A549 Myers RAD21 ENCSR000DYE r=0.36
A549 Myers YY1 ENCSR000BPM r=0.35
A549 Myers CEBPB ENCSR000BUB r=0.34
A549 Myers USF1 ENCSR000BHX r=0.34
A549 Myers REST ENCSR000BQP r=0.33
A549 Myers RAD21 ENCSR000BUC r=0.33
A549 Myers SIN3A ENCSR000BRM r=0.32
A549 Myers ETS1 ENCSR000BPU r=0.31
A549 Myers USF1 ENCSR000BJB r=0.30
A549 Myers NR3C1 ENCSR000BJR r=0.30
A549 Myers CTCF ENCSR000DYD r=0.30
A549 Myers USF1 ENCSR000BPV r=0.29
A549 Myers GABPA ENCSR000BPY r=0.28
A549 Myers SIX5 ENCSR000BRL r=0.28
A549 Myers TCF12 ENCSR000BQQ r=0.28
A549 Myers ZBTB33 ENCSR000BPZ r=0.28
A549 Myers CEBPB ENCSR000DYI r=0.27
A549 Myers FOXA2 ENCSR000BRE r=0.27
A549 Myers ELF1 ENCSR000BPT r=0.25
A549 Myers CTCF ENCSR000DNA r=0.25
A549 Myers FOSL2 ENCSR000BQO r=0.24
A549 Myers CTCF ENCSR000AUF r=0.22
A549 Myers ATF3 ENCSR000BPS r=0.22
A549 Myers EP300 ENCSR000BPW r=0.21
A549 Myers JUND ENCSR000BRF r=0.21
A549 Myers CTCF ENCSR000AUE r=0.20
A549 Myers BCL3 ENCSR000BQH r=0.20
A549 Myers CTCF ENCSR000BHV r=0.18
A549 Myers NR3C1 ENCSR000BHF r=0.17
A549 Myers CTCF ENCSR000BHW r=0.17
A549 Myers CTCF ENCSR000DPF r=0.16
A549 Myers NR3C1 ENCSR000BHE r=0.10
A549 Myers FOXA1 ENCSR000BPX r=0.08
A549 Myers NR3C1 ENCSR000BHG r=0.08

6,791 peaks (download )

H1-hESC - Myers - ENCSR000BSI

H1-hESC Myers E2F6 ENCSR000BSI r=1.00
H1-hESC Myers MAX ENCSR000BSJ r=0.81
H1-hESC Myers MAX ENCSR000EUP r=0.64
H1-hESC Myers MYC ENCSR000EBY r=0.47
H1-hESC Myers HDAC2 ENCSR000AVB r=0.46
H1-hESC Myers MXI1 ENCSR000EBR r=0.44
H1-hESC Myers RBBP5 ENCSR000AQC r=0.42
H1-hESC Myers CTBP2 ENCSR000EUO r=0.41
H1-hESC Myers USF2 ENCSR000ECD r=0.41
H1-hESC Myers KDM4A ENCSR000AVC r=0.40
H1-hESC Myers CREB1 ENCSR000BSN r=0.40
H1-hESC Myers EP300 ENCSR000AUQ r=0.39
H1-hESC Myers SIN3A ENCSR000EBO r=0.38
H1-hESC Myers JUND ENCSR000EBZ r=0.36
H1-hESC Myers CHD7 ENCSR000AVA r=0.36
H1-hESC Myers BACH1 ENCSR000EBQ r=0.35
H1-hESC Myers POLR2A ENCSR000DLJ r=0.34
H1-hESC Myers TEAD4 ENCSR000BRY r=0.33
H1-hESC Myers ZNF143 ENCSR000EBW r=0.33
H1-hESC Myers TBP ENCSR000ECB r=0.32
H1-hESC Myers PHF8 ENCSR000ATK r=0.31
H1-hESC Myers RAD21 ENCSR000ECE r=0.30
H1-hESC Myers CEBPB ENCSR000EBV r=0.30
H1-hESC Myers CTCF ENCSR000DLK r=0.29
H1-hESC Myers BRCA1 ENCSR000EBX r=0.29
H1-hESC Myers USF1 ENCSR000BIU r=0.29
H1-hESC Myers SUZ12 ENCSR000ATS r=0.29
H1-hESC Myers NRF1 ENCSR000ECC r=0.28
H1-hESC Myers TAF1 ENCSR000BHO r=0.28
H1-hESC Myers SIRT6 ENCSR000AUS r=0.27
H1-hESC Myers HDAC6 ENCSR000ATQ r=0.27
H1-hESC Myers GABPA ENCSR000BIW r=0.26
H1-hESC Myers YY1 ENCSR000BKD r=0.26
H1-hESC Myers JUN ENCSR000ECA r=0.25
H1-hESC Myers CTCF ENCSR000AMF r=0.25
H1-hESC Myers POLR2A ENCSR000BHN r=0.23
H1-hESC Myers MYC ENCSR000DLI r=0.22
H1-hESC Myers KDM5B ENCSR000AUR r=0.22
H1-hESC Myers SP1 ENCSR000BIR r=0.21
H1-hESC Myers MAFK ENCSR000EBS r=0.21
H1-hESC Myers CTCF ENCSR000BNH r=0.20
H1-hESC Myers RFX5 ENCSR000ECF r=0.19
H1-hESC Myers RAD21 ENCSR000BLD r=0.19
H1-hESC Myers SUZ12 ENCSR000EUQ r=0.18
H1-hESC Myers CHD1 ENCSR000EBU r=0.18
H1-hESC Myers EZH2 ENCSR000ASY r=0.18
H1-hESC Myers SAP30 ENCSR000ATR r=0.17
H1-hESC Myers KDM5A ENCSR000AQL r=0.17
H1-hESC Myers SIN3A ENCSR000BIS r=0.16
H1-hESC Myers ATF2 ENCSR000BQU r=0.16
H1-hESC Myers SP4 ENCSR000BQV r=0.15
H1-hESC Myers ATF3 ENCSR000BKC r=0.14
H1-hESC Myers CHD1 ENCSR000AQK r=0.12
H1-hESC Myers EGR1 ENCSR000BJA r=0.12
H1-hESC Myers HDAC2 ENCSR000BNR r=0.12
H1-hESC Myers TAF7 ENCSR000BLU r=0.12
H1-hESC Myers JUND ENCSR000BKP r=0.12
H1-hESC Myers TCF12 ENCSR000BIT r=0.11
H1-hESC Myers SP2 ENCSR000BQG r=0.10
H1-hESC Myers FOSL1 ENCSR000BNS r=0.10
H1-hESC Myers EP300 ENCSR000BKK r=0.09
H1-hESC Myers SRF ENCSR000BIV r=0.09
H1-hESC Myers SIX5 ENCSR000BIQ r=0.07
H1-hESC Myers REST ENCSR000BHM r=0.06
H1-hESC Myers NANOG ENCSR000BMT r=0.04
H1-hESC Myers RXRA ENCSR000BJW r=0.04
H1-hESC Myers BCL11A ENCSR000BMJ r=0.04
H1-hESC Myers BCL11A ENCSR000BIP r=0.02
H1-hESC Myers ZNF274 ENCSR000EUN r=-0.02

10,000 randomly-selected peaks from a total of 12,733 (download )

HeLa-S3 - Farnham - ENCSR000EVK

HeLa-S3 Farnham E2F6 ENCSR000EVK r=1.00
HeLa-S3 Farnham MAX ENCSR000ECN r=0.74
HeLa-S3 Farnham MYC ENCSR000EZD r=0.67
HeLa-S3 Farnham MAX ENCSR000EZF r=0.67
HeLa-S3 Farnham E2F4 ENCSR000EVL r=0.62
HeLa-S3 Farnham E2F1 ENCSR000EVJ r=0.59
HeLa-S3 Farnham MXI1 ENCSR000ECU r=0.59
HeLa-S3 Farnham MYC ENCSR000DLN r=0.58
HeLa-S3 Farnham SMARCB1 ENCSR000EDK r=0.56
HeLa-S3 Farnham POLR2A ENCSR000EZL r=0.55
HeLa-S3 Farnham POLR2A ENCSR000DLM r=0.55
HeLa-S3 Farnham RCOR1 ENCSR000ECM r=0.53
HeLa-S3 Farnham ZKSCAN1 ENCSR000ECJ r=0.52
HeLa-S3 Farnham ELK1 ENCSR000ECI r=0.52
HeLa-S3 Farnham HCFC1 ENCSR000ECH r=0.50
HeLa-S3 Farnham SMC3 ENCSR000ECS r=0.44
HeLa-S3 Farnham POLR2A ENCSR000BGO r=0.43
HeLa-S3 Farnham MAFK ENCSR000ECK r=0.43
HeLa-S3 Farnham STAT1 ENCSR000EZK r=0.42
HeLa-S3 Farnham KAT2A ENCSR000ECR r=0.39
HeLa-S3 Farnham ZNF143 ENCSR000ECO r=0.38
HeLa-S3 Farnham BRCA1 ENCSR000EDB r=0.37
HeLa-S3 Farnham RFX5 ENCSR000ECX r=0.37
HeLa-S3 Farnham ELK4 ENCSR000EVI r=0.36
HeLa-S3 Farnham TCF7L2 ENCSR000EVE r=0.35
HeLa-S3 Farnham SMARCC1 ENCSR000EDM r=0.35
HeLa-S3 Farnham FOS ENCSR000EZE r=0.34
HeLa-S3 Farnham NFYA ENCSR000DNS r=0.33
HeLa-S3 Farnham USF2 ENCSR000ECW r=0.32
HeLa-S3 Farnham SMARCC2 ENCSR000EDL r=0.31
HeLa-S3 Farnham NRF1 ENCSR000EDJ r=0.30
HeLa-S3 Farnham CEBPB ENCSR000EDA r=0.27
HeLa-S3 Farnham NR2C2 ENCSR000EVN r=0.27
HeLa-S3 Farnham TBP ENCSR000EDD r=0.26
HeLa-S3 Farnham JUND ENCSR000EDH r=0.26
HeLa-S3 Farnham SMARCA4 ENCSR000EZC r=0.25
HeLa-S3 Farnham TAF1 ENCSR000BHT r=0.25
HeLa-S3 Farnham NFYB ENCSR000DNR r=0.23
HeLa-S3 Farnham GABPA ENCSR000BHS r=0.23
HeLa-S3 Farnham TCF7L2 ENCSR000EVF r=0.23
HeLa-S3 Farnham CTCF ENCSR000DLO r=0.23
HeLa-S3 Farnham CTCF ENCSR000DUB r=0.20
HeLa-S3 Farnham RAD21 ENCSR000EDE r=0.20
HeLa-S3 Farnham JUN ENCSR000EDG r=0.17
HeLa-S3 Farnham ZNF274 ENCSR000EVG r=0.16
HeLa-S3 Farnham CTCF ENCSR000AOA r=0.15
HeLa-S3 Farnham PRDM1 ENCSR000ECY r=0.15
HeLa-S3 Farnham STAT3 ENCSR000EDC r=0.14
HeLa-S3 Farnham IRF3 ENCSR000EDF r=0.14
HeLa-S3 Farnham SUPT20H ENCSR000ECQ r=0.14
HeLa-S3 Farnham EP300 ENCSR000ECV r=0.12
HeLa-S3 Farnham REST ENCSR000BMN r=0.09
HeLa-S3 Farnham EZH2 ENCSR000ATC r=0.07
HeLa-S3 Farnham BRF2 ENCSR000DNV r=0.00
HeLa-S3 Farnham POLR3A ENCSR000DNU r=-0.01
HeLa-S3 Farnham GTF3C2 ENCSR000DNY r=-0.04
HeLa-S3 Farnham ZZZ3 ENCSR000DNT r=-0.10
HeLa-S3 Farnham BDP1 ENCSR000DNX r=-0.10
HeLa-S3 Farnham BRF1 ENCSR000DNW r=-0.20

4,775 peaks (download )

K562 - Farnham - ENCSR000EWJ

K562 Farnham E2F6 ENCSR000EWJ r=1.00
K562 Farnham MAX ENCSR000EFV r=0.76
K562 Farnham MAX ENCSR000BLP r=0.71
K562 Farnham MAX ENCSR000FAE r=0.69
K562 Farnham MYC ENCSR000EGJ r=0.67
K562 Farnham MYC ENCSR000EGS r=0.66
K562 Farnham MYC ENCSR000FAG r=0.64
K562 Farnham E2F4 ENCSR000EWL r=0.64
K562 Farnham E2F6 ENCSR000BLI r=0.63
K562 Farnham MYC ENCSR000DLZ r=0.63
K562 Farnham MYC ENCSR000EZU r=0.63
K562 Farnham MYC ENCSR000EZV r=0.61
K562 Farnham MYC ENCSR000FAZ r=0.61
K562 Farnham SETDB1 ENCSR000EWI r=0.60
K562 Farnham HMGN3 ENCSR000DOB r=0.58
K562 Farnham JUN ENCSR000EFS r=0.55
K562 Farnham CCNT2 ENCSR000DOA r=0.55
K562 Farnham BHLHE40 ENCSR000EGV r=0.53
K562 Farnham CBX3 ENCSR000BRT r=0.51
K562 Farnham POLR2A ENCSR000DLY r=0.50
K562 Farnham MXI1 ENCSR000EGZ r=0.50
K562 Farnham RCOR1 ENCSR000EGG r=0.49
K562 Farnham TBL1XR1 ENCSR000EGA r=0.48
K562 Farnham SETDB1 ENCSR000AUT r=0.48
K562 Farnham POLR2A ENCSR000FAW r=0.47
K562 Farnham POLR2A ENCSR000FAJ r=0.47
K562 Farnham HDAC1 ENCSR000AQF r=0.47
K562 Farnham KDM5B ENCSR000AQA r=0.47
K562 Farnham RBBP5 ENCSR000AQI r=0.47
K562 Farnham HDAC2 ENCSR000AQG r=0.46
K562 Farnham ZMIZ1 ENCSR000EFQ r=0.46
K562 Farnham POLR2A ENCSR000FAY r=0.46
K562 Farnham JUN ENCSR000FAH r=0.45
K562 Farnham JUND ENCSR000EGN r=0.45
K562 Farnham POLR2A ENCSR000EHP r=0.44
K562 Farnham POLR2A ENCSR000FAX r=0.44
K562 Farnham CREB1 ENCSR000BSO r=0.44
K562 Farnham PHF8 ENCSR000AQH r=0.44
K562 Farnham IRF1 ENCSR000EGK r=0.44
K562 Farnham STAT1 ENCSR000EHJ r=0.43
K562 Farnham STAT2 ENCSR000FAT r=0.43
K562 Farnham IRF1 ENCSR000EGL r=0.42
K562 Farnham JUN ENCSR000EGH r=0.42
K562 Farnham RCOR1 ENCSR000EGC r=0.42
K562 Farnham SAP30 ENCSR000AQJ r=0.41
K562 Farnham POLR2A ENCSR000BMR r=0.41
K562 Farnham TBL1XR1 ENCSR000EGB r=0.41
K562 Farnham ELK1 ENCSR000EFU r=0.41
K562 Farnham IRF1 ENCSR000EGT r=0.40
K562 Farnham CHD7 ENCSR000AVD r=0.40
K562 Farnham TRIM28 ENCSR000BRW r=0.40
K562 Farnham SMC3 ENCSR000EGW r=0.39
K562 Farnham YY1 ENCSR000BKU r=0.39
K562 Farnham HDAC6 ENCSR000ATJ r=0.39
K562 Farnham RNF2 ENCSR000AUA r=0.38
K562 Farnham HCFC1 ENCSR000EFN r=0.38
K562 Farnham TAF1 ENCSR000BKS r=0.38
K562 Farnham ATF3 ENCSR000BNU r=0.38
K562 Farnham ELF1 ENCSR000BMD r=0.38
K562 Farnham GTF2B ENCSR000DOE r=0.37
K562 Farnham EP300 ENCSR000EGE r=0.37
K562 Farnham ATF1 ENCSR000DNZ r=0.37
K562 Farnham KAT2B ENCSR000ATZ r=0.37
K562 Farnham ZNF263 ENCSR000EWN r=0.36
K562 Farnham STAT1 ENCSR000EHK r=0.36
K562 Farnham TBP ENCSR000EHA r=0.36
K562 Farnham USF1 ENCSR000BKT r=0.36
K562 Farnham POLR2A ENCSR000EHL r=0.36
K562 Farnham GATA1 ENCSR000EFT r=0.35
K562 Farnham ATF3 ENCSR000DOG r=0.35
K562 Farnham STAT1 ENCSR000FAU r=0.34
K562 Farnham CBX3 ENCSR000ATV r=0.33
K562 Farnham CEBPD ENCSR000BVY r=0.33
K562 Farnham UBTF ENCSR000EFZ r=0.33
K562 Farnham WHSC1 ENCSR000AVE r=0.32
K562 Farnham STAT1 ENCSR000FAV r=0.32
K562 Farnham EGR1 ENCSR000BNE r=0.32
K562 Farnham ETS1 ENCSR000BKQ r=0.32
K562 Farnham NFE2 ENCSR000FAF r=0.31
K562 Farnham STAT2 ENCSR000FBC r=0.30
K562 Farnham ARID3A ENCSR000EFY r=0.30
K562 Farnham NRF1 ENCSR000EHH r=0.30
K562 Farnham STAT5A ENCSR000BRR r=0.30
K562 Farnham ZNF384 ENCSR000EFP r=0.30
K562 Farnham YY1 ENCSR000EWF r=0.29
K562 Farnham NFYA ENCSR000EGR r=0.29
K562 Farnham UBTF ENCSR000EFW r=0.29
K562 Farnham USF2 ENCSR000EHG r=0.29
K562 Farnham CTCF ENCSR000EGM r=0.29
K562 Farnham TEAD4 ENCSR000BRK r=0.29
K562 Farnham GTF3C2 ENCSR000DOD r=0.28
K562 Farnham NR2F2 ENCSR000BRS r=0.28
K562 Farnham REST ENCSR000BMW r=0.28
K562 Farnham FOS ENCSR000FAI r=0.27
K562 Farnham ZNF143 ENCSR000EGP r=0.27
K562 Farnham JUN ENCSR000EZX r=0.27
K562 Farnham GATA1 ENCSR000EWM r=0.26
K562 Farnham SIRT6 ENCSR000AUB r=0.26
K562 Farnham MAFK ENCSR000EGX r=0.26
K562 Farnham HDAC2 ENCSR000BMG r=0.26
K562 Farnham PML ENCSR000BQY r=0.26
K562 Farnham BACH1 ENCSR000EGD r=0.26
K562 Farnham CTCF ENCSR000BPJ r=0.25
K562 Farnham NCOR1 ENCSR000ATY r=0.25
K562 Farnham CUX1 ENCSR000EFO r=0.25
K562 Farnham EP300 ENCSR000EGY r=0.25
K562 Farnham NFYB ENCSR000EGQ r=0.24
K562 Farnham CTCFL ENCSR000BNK r=0.24
K562 Farnham CTCF ENCSR000DMA r=0.24
K562 Farnham CTCF ENCSR000AKO r=0.24
K562 Farnham JUN ENCSR000EZT r=0.24
K562 Farnham CTCF ENCSR000DWE r=0.23
K562 Farnham GATA2 ENCSR000EWG r=0.23
K562 Farnham SMARCA4 ENCSR000EHO r=0.23
K562 Farnham SETDB1 ENCSR000EWD r=0.23
K562 Farnham EP300 ENCSR000AQB r=0.23
K562 Farnham SMARCB1 ENCSR000EHN r=0.23
K562 Farnham KDM1A ENCSR000ATX r=0.23
K562 Farnham GABPA ENCSR000BLO r=0.23
K562 Farnham THAP1 ENCSR000BNN r=0.22
K562 Farnham SIRT6 ENCSR000DOH r=0.21
K562 Farnham TAL1 ENCSR000EHB r=0.21
K562 Farnham SRF ENCSR000BLK r=0.21
K562 Farnham CEBPB ENCSR000BRQ r=0.21
K562 Farnham SIN3A ENCSR000BLR r=0.21
K562 Farnham RFX5 ENCSR000EGO r=0.20
K562 Farnham SUZ12 ENCSR000AUC r=0.20
K562 Farnham CHD1 ENCSR000AQD r=0.20
K562 Farnham ZNF274 ENCSR000EVX r=0.19
K562 Farnham ZBTB7A ENCSR000BME r=0.19
K562 Farnham CHD4 ENCSR000ATL r=0.19
K562 Farnham RAD21 ENCSR000FAD r=0.19
K562 Farnham IRF1 ENCSR000EGU r=0.19
K562 Farnham TRIM28 ENCSR000EVY r=0.19
K562 Farnham JUN ENCSR000EZW r=0.18
K562 Farnham SP2 ENCSR000BNL r=0.18
K562 Farnham CEBPB ENCSR000EHE r=0.17
K562 Farnham CREBBP ENCSR000ATT r=0.16
K562 Farnham RAD21 ENCSR000BKV r=0.16
K562 Farnham REST ENCSR000ATM r=0.16
K562 Farnham TAF7 ENCSR000BNM r=0.16
K562 Farnham YY1 ENCSR000BMH r=0.15
K562 Farnham SPI1 ENCSR000BGW r=0.15
K562 Farnham SP1 ENCSR000BKO r=0.15
K562 Farnham BRF2 ENCSR000DOC r=0.15
K562 Farnham FOSL1 ENCSR000BMV r=0.13
K562 Farnham ZBTB33 ENCSR000BKF r=0.13
K562 Farnham MEF2A ENCSR000BNV r=0.12
K562 Farnham XRCC4 ENCSR000FAC r=0.12
K562 Farnham SIX5 ENCSR000BGX r=0.12
K562 Farnham MAFF ENCSR000EGI r=0.12
K562 Farnham GATA2 ENCSR000BKM r=0.12
K562 Farnham EZH2 ENCSR000AQE r=0.10
K562 Farnham NR2C2 ENCSR000EWH r=0.09
K562 Farnham SIX5 ENCSR000BNW r=0.08
K562 Farnham POLR3A ENCSR000DOI r=0.05
K562 Farnham BRF1 ENCSR000DOJ r=0.04
K562 Farnham CBX2 ENCSR000ATU r=0.03
K562 Farnham CBX8 ENCSR000ATW r=0.02
K562 Farnham BDP1 ENCSR000DOK r=0.02
K562 Farnham POLR3G ENCSR000EHQ r=0.01
K562 Farnham ZNF274 ENCSR000EWE r=-0.15

10,000 randomly-selected peaks from a total of 16,312 (download )

K562 - Myers - ENCSR000BLI

K562 Myers E2F6 ENCSR000BLI r=1.00
K562 Myers E2F6 ENCSR000EWJ r=0.61
K562 Myers MAX ENCSR000BLP r=0.49
K562 Myers MAX ENCSR000EFV r=0.48
K562 Myers MAX ENCSR000FAE r=0.44
K562 Myers MYC ENCSR000EGJ r=0.43
K562 Myers E2F4 ENCSR000EWL r=0.42
K562 Myers MYC ENCSR000EGS r=0.42
K562 Myers MYC ENCSR000DLZ r=0.41
K562 Myers MYC ENCSR000FAG r=0.40
K562 Myers MYC ENCSR000EZU r=0.39
K562 Myers CCNT2 ENCSR000DOA r=0.38
K562 Myers MYC ENCSR000EZV r=0.37
K562 Myers MYC ENCSR000FAZ r=0.37
K562 Myers HMGN3 ENCSR000DOB r=0.36
K562 Myers JUN ENCSR000EFS r=0.35
K562 Myers BHLHE40 ENCSR000EGV r=0.33
K562 Myers SETDB1 ENCSR000EWI r=0.33
K562 Myers CBX3 ENCSR000BRT r=0.31
K562 Myers RCOR1 ENCSR000EGG r=0.31
K562 Myers MXI1 ENCSR000EGZ r=0.31
K562 Myers POLR2A ENCSR000FAJ r=0.30
K562 Myers ZMIZ1 ENCSR000EFQ r=0.30
K562 Myers POLR2A ENCSR000FAW r=0.29
K562 Myers TBL1XR1 ENCSR000EGA r=0.29
K562 Myers POLR2A ENCSR000DLY r=0.29
K562 Myers IRF1 ENCSR000EGK r=0.28
K562 Myers JUN ENCSR000FAH r=0.28
K562 Myers CREB1 ENCSR000BSO r=0.28
K562 Myers POLR2A ENCSR000EHP r=0.28
K562 Myers JUND ENCSR000EGN r=0.28
K562 Myers POLR2A ENCSR000FAY r=0.28
K562 Myers IRF1 ENCSR000EGL r=0.28
K562 Myers RBBP5 ENCSR000AQI r=0.27
K562 Myers KDM5B ENCSR000AQA r=0.27
K562 Myers ELF1 ENCSR000BMD r=0.27
K562 Myers JUN ENCSR000EGH r=0.27
K562 Myers IRF1 ENCSR000EGT r=0.27
K562 Myers POLR2A ENCSR000BMR r=0.27
K562 Myers POLR2A ENCSR000FAX r=0.27
K562 Myers TBL1XR1 ENCSR000EGB r=0.27
K562 Myers YY1 ENCSR000BKU r=0.26
K562 Myers STAT2 ENCSR000FAT r=0.26
K562 Myers TAF1 ENCSR000BKS r=0.26
K562 Myers TRIM28 ENCSR000BRW r=0.25
K562 Myers PHF8 ENCSR000AQH r=0.25
K562 Myers SETDB1 ENCSR000AUT r=0.25
K562 Myers STAT1 ENCSR000EHJ r=0.25
K562 Myers EP300 ENCSR000EGE r=0.25
K562 Myers RCOR1 ENCSR000EGC r=0.25
K562 Myers HDAC1 ENCSR000AQF r=0.25
K562 Myers ATF3 ENCSR000BNU r=0.25
K562 Myers GTF2B ENCSR000DOE r=0.25
K562 Myers EGR1 ENCSR000BNE r=0.25
K562 Myers ELK1 ENCSR000EFU r=0.24
K562 Myers HDAC2 ENCSR000AQG r=0.24
K562 Myers HCFC1 ENCSR000EFN r=0.24
K562 Myers USF1 ENCSR000BKT r=0.24
K562 Myers TBP ENCSR000EHA r=0.24
K562 Myers RNF2 ENCSR000AUA r=0.23
K562 Myers SMC3 ENCSR000EGW r=0.23
K562 Myers GATA1 ENCSR000EFT r=0.23
K562 Myers SAP30 ENCSR000AQJ r=0.23
K562 Myers ATF1 ENCSR000DNZ r=0.22
K562 Myers STAT1 ENCSR000EHK r=0.22
K562 Myers ARID3A ENCSR000EFY r=0.21
K562 Myers CHD7 ENCSR000AVD r=0.21
K562 Myers CEBPD ENCSR000BVY r=0.21
K562 Myers KAT2B ENCSR000ATZ r=0.21
K562 Myers ATF3 ENCSR000DOG r=0.21
K562 Myers NRF1 ENCSR000EHH r=0.20
K562 Myers STAT1 ENCSR000FAU r=0.20
K562 Myers ETS1 ENCSR000BKQ r=0.20
K562 Myers TEAD4 ENCSR000BRK r=0.20
K562 Myers HDAC6 ENCSR000ATJ r=0.20
K562 Myers STAT1 ENCSR000FAV r=0.20
K562 Myers MAFK ENCSR000EGX r=0.19
K562 Myers STAT2 ENCSR000FBC r=0.19
K562 Myers ZNF384 ENCSR000EFP r=0.19
K562 Myers STAT5A ENCSR000BRR r=0.19
K562 Myers HDAC2 ENCSR000BMG r=0.19
K562 Myers REST ENCSR000BMW r=0.19
K562 Myers NFE2 ENCSR000FAF r=0.18
K562 Myers GTF3C2 ENCSR000DOD r=0.18
K562 Myers NFYA ENCSR000EGR r=0.18
K562 Myers FOS ENCSR000FAI r=0.18
K562 Myers ZNF263 ENCSR000EWN r=0.18
K562 Myers POLR2A ENCSR000EHL r=0.17
K562 Myers PML ENCSR000BQY r=0.17
K562 Myers CTCF ENCSR000EGM r=0.17
K562 Myers NR2F2 ENCSR000BRS r=0.17
K562 Myers YY1 ENCSR000EWF r=0.17
K562 Myers CTCFL ENCSR000BNK r=0.17
K562 Myers ZNF143 ENCSR000EGP r=0.17
K562 Myers JUN ENCSR000EZX r=0.17
K562 Myers BACH1 ENCSR000EGD r=0.17
K562 Myers USF2 ENCSR000EHG r=0.17
K562 Myers UBTF ENCSR000EFZ r=0.17
K562 Myers CTCF ENCSR000BPJ r=0.16
K562 Myers EP300 ENCSR000EGY r=0.16
K562 Myers CUX1 ENCSR000EFO r=0.16
K562 Myers WHSC1 ENCSR000AVE r=0.16
K562 Myers SMARCB1 ENCSR000EHN r=0.16
K562 Myers CBX3 ENCSR000ATV r=0.16
K562 Myers SMARCA4 ENCSR000EHO r=0.16
K562 Myers NFYB ENCSR000EGQ r=0.15
K562 Myers NCOR1 ENCSR000ATY r=0.15
K562 Myers TAL1 ENCSR000EHB r=0.15
K562 Myers JUN ENCSR000EZT r=0.15
K562 Myers GABPA ENCSR000BLO r=0.15
K562 Myers KDM1A ENCSR000ATX r=0.15
K562 Myers CTCF ENCSR000DMA r=0.14
K562 Myers THAP1 ENCSR000BNN r=0.14
K562 Myers SRF ENCSR000BLK r=0.14
K562 Myers GATA1 ENCSR000EWM r=0.14
K562 Myers ZNF274 ENCSR000EVX r=0.14
K562 Myers SIN3A ENCSR000BLR r=0.14
K562 Myers CEBPB ENCSR000BRQ r=0.14
K562 Myers SIRT6 ENCSR000DOH r=0.14
K562 Myers UBTF ENCSR000EFW r=0.14
K562 Myers SIRT6 ENCSR000AUB r=0.14
K562 Myers SETDB1 ENCSR000EWD r=0.13
K562 Myers RFX5 ENCSR000EGO r=0.13
K562 Myers EP300 ENCSR000AQB r=0.13
K562 Myers GATA2 ENCSR000EWG r=0.13
K562 Myers CTCF ENCSR000DWE r=0.13
K562 Myers ZBTB7A ENCSR000BME r=0.13
K562 Myers JUN ENCSR000EZW r=0.13
K562 Myers CTCF ENCSR000AKO r=0.13
K562 Myers TRIM28 ENCSR000EVY r=0.12
K562 Myers IRF1 ENCSR000EGU r=0.12
K562 Myers TAF7 ENCSR000BNM r=0.12
K562 Myers SP2 ENCSR000BNL r=0.12
K562 Myers CHD1 ENCSR000AQD r=0.12
K562 Myers CHD4 ENCSR000ATL r=0.11
K562 Myers RAD21 ENCSR000BKV r=0.11
K562 Myers RAD21 ENCSR000FAD r=0.11
K562 Myers CEBPB ENCSR000EHE r=0.11
K562 Myers YY1 ENCSR000BMH r=0.10
K562 Myers SUZ12 ENCSR000AUC r=0.10
K562 Myers SP1 ENCSR000BKO r=0.10
K562 Myers MAFF ENCSR000EGI r=0.10
K562 Myers MEF2A ENCSR000BNV r=0.09
K562 Myers BRF2 ENCSR000DOC r=0.09
K562 Myers GATA2 ENCSR000BKM r=0.09
K562 Myers SPI1 ENCSR000BGW r=0.09
K562 Myers FOSL1 ENCSR000BMV r=0.09
K562 Myers REST ENCSR000ATM r=0.08
K562 Myers CREBBP ENCSR000ATT r=0.08
K562 Myers ZBTB33 ENCSR000BKF r=0.07
K562 Myers XRCC4 ENCSR000FAC r=0.07
K562 Myers SIX5 ENCSR000BGX r=0.06
K562 Myers SIX5 ENCSR000BNW r=0.06
K562 Myers EZH2 ENCSR000AQE r=0.04
K562 Myers POLR3A ENCSR000DOI r=0.03
K562 Myers BRF1 ENCSR000DOJ r=0.03
K562 Myers NR2C2 ENCSR000EWH r=0.03
K562 Myers BDP1 ENCSR000DOK r=0.02
K562 Myers POLR3G ENCSR000EHQ r=0.01
K562 Myers CBX2 ENCSR000ATU r=0.00
K562 Myers CBX8 ENCSR000ATW r=-0.00
K562 Myers ZNF274 ENCSR000EWE r=-0.08

10,000 randomly-selected peaks from a total of 24,570 (download )

Notes

Peaks (left to right in the heatmap) are sorted by the descending order of [-log10(q-value), -log10(p-value), TF ChIP-seq signal].

Average Profiles of Nucleosomes around the Summit of ChIP-seq Peaks

K562 - Farnham - ENCSR000EWJ

K562 - Myers - ENCSR000BLI

Notes

Average nucleosome occupancy profiles in GM12878 and K562 cells are shown for the [-2 kb, +2 kb] window centered on the summits of the TF ChIP-seq peaks, separately for peaks that are proximal to an annotated transcription start site (red lines) and for peaks that are distal to all annotated transcription start sites (blue lines), as defined in the Histone section.