This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene.RefSeq, Feb 2014
C-terminal-binding protein 2 also known as CtBP2 is a protein that in humans is encoded by the CTBP2 gene.wikipedia
Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks
H1-hESC - Farnham - ENCSR000EUO

Legend
- H2AFZ
- H3K27ac
- H3K27me3
- H3K36me3
- H3K4me1
- H3K4me2
- H3K4me3
- H3K79me2
- H3K9ac
- H3K9me1
- H3K9me3
- H4K20me1
- H2AFZ
- H3K27ac
- H3K27me3
- H3K36me3
- H3K4me1
- H3K4me2
- H3K4me3
- H3K79me2
- H3K9ac
- H3K9me1
- H3K9me3
- H4K20me1
Notes
Average histone modification profiles are shown for the [-2 kb, +2 kb] window around the summits of TF ChIP-seq peaks. Profile are shown separately for peaks that are proximal ([-1 kb, +1 kb]; ending in '-p') to an annotated transcript start site (TSS) and for peaks that are distal (>1 kb; ending in '-d') to all annotated TSS. TSS-proximal profiles are arranged such that the nearest transcript proceeds towards the right.
Motifs Enriched in the Top 500 ChIP-seq Peaks
H1-hESC - Farnham - ENCSR000EUO
MEME outputNotes
The top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Up to five motifs are reported (1 to 5) if they meet the criteria defined by our pipeline.
H1-hESC - Farnham - ENCSR000EUO
H1-hESC |
![]() |
---|---|
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
Notes
ChIP-seq peaks (left to right in the heatmap) for the current TF are sorted by descending TF ChIP-seq signal. The ChIP-seq signals of histone modifications are plotted for the genomic regions that correspond to the peaks of the current TF in the same order. The Pearson correlation coefficient (r) of the histone modification ChIP-seq signal with the TF ChIP-seq signal is shown.

H1-hESC - Farnham - ENCSR000EUO
H1-hESC |
![]() |
---|---|
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
H1-hESC |
![]() |
Notes
Peaks (left to right in the heatmap) are sorted by the descending order of [-log10(q-value), -log10(p-value), TF ChIP-seq signal].

Average Profiles of Nucleosomes around the Summit of ChIP-seq Peaks
No GM12878 or K562 datasets available.Notes
Average nucleosome occupancy profiles in GM12878 and K562 cells are shown for the [-2 kb, +2 kb] window centered on the summits of the TF ChIP-seq peaks, separately for peaks that are proximal to an annotated transcription start site (red lines) and for peaks that are distal to all annotated transcription start sites (blue lines), as defined in the Histone section.