Welcome to Factorbook!

The Encyclopedia of DNA Elements (ENCODE) consortium aims to identify all functional elements in the human genome. These elements include expressed transcripts and genomic regions bound by transcription factors (TFs), occupied by nucleosomes, occupied by nucleosomes with modified histones, or hypersensitive to DNase I cleavage, etc. Chromatin Immunoprecipitation (ChIP-seq) is an experimental technique for detecting TF binding in living cells, and the genomic regions bound by TFs are called ChIP-seq peaks. Transcription factor binding sites (TFBS) are the 6-25 nucleotide long genomic positions bound by TFs. TFBS tend to be located near the summits of ChIP-seq peaks.

This website organizes the analysis results of ENCODE TF ChIP-seq data, integrated with other ENCODE data such as ChIP-seq of histone marks and nucleosome occupancy.

167 TFs
837 experiments
Citation: J Wang, J Zhuang, S Iyer, XY Lin, et al. Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors. Genome Research 22 (9), 1798-1812